School of Ethnic Medicine, Yunnan University of Chinese Medicine, Kunming 650500, Yunnan, People's Republic of China.
Key Laboratory of Modern Research on Ethnic Medicine in Colleges of Yunnan Province, Kunming 650500, Yunnan, People's Republic of China.
J Nat Prod. 2022 Feb 25;85(2):405-414. doi: 10.1021/acs.jnatprod.1c00977. Epub 2022 Jan 26.
Thirty-five tigliane diterpenoids and two -kaurane diterpenoids were isolated from the leaves of , and, among them, compounds - were characterized as new tigliane diterpenoids. The structures of compounds - were determined by analysis of their HRESIMS, NMR, and ECD data and by chemical methods. The isolates were assayed for their larvicidal, antifungal, and α-glucosidase inhibitory activities, and compounds - were found to possess larvicidal activities against with LC values of 0.19, 0.16, and 0.26 μM, respectively, comparable to the LC of 0.14 μM for the positive control, flubendiamide.
从 叶片中分离得到 35 种新的贝壳杉烷二萜和 2 种贝壳杉烷二萜，其中化合物 被鉴定为新的贝壳杉烷二萜。通过分析其 HRESIMS、NMR 和 ECD 数据以及化学方法确定了化合物 的结构。对分离得到的化合物进行了杀虫、抗真菌和α-葡萄糖苷酶抑制活性测试，发现化合物 - 对 具有杀虫活性，LC 值分别为 0.19、0.16 和 0.26 μM，与阳性对照氟苯虫酰胺的 LC 值 0.14 μM 相当。
