来自广西巴豆的细胞毒性8,9-断-对映-贝壳杉烷二萜类化合物。

Cytotoxic 8,9-seco-ent-kaurane diterpenoids from Croton kongensis.

作者信息

Shi Shu-Qin, Fan Yao-Yue, Xu Cheng-Hui, Ding Jian, Wang Guan-Wu, Yue Jian-Min

机构信息

a Nano Science and Technology Institute, University of Science and Technology of China , Suzhou 215123 , China.

b State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China.

出版信息

J Asian Nat Prod Res. 2018 Oct;20(10):920-927. doi: 10.1080/10286020.2017.1373100. Epub 2017 Sep 12.

DOI:10.1080/10286020.2017.1373100

PMID:28895443

Abstract

Chemical study on the ethanolic extract generated from the aerial parts of Croton kongensis led to the isolation of three new 8,9-seco-ent-kaurane diterpenoids, kongeniods A‒C (1‒3), together with seven known analogs (4-10). The structures of these compounds were assigned by spectroscopic data analysis. The vitro cytotoxic tests showed that compounds 1-3 exhibited strong activities against HL-60 cell lines with IC values of 0.47, 0.58, and 1.27 μM, respectively.

摘要

对海南巴豆地上部分乙醇提取物的化学研究，导致分离出三种新的8,9-断-对映-贝壳杉烷二萜类化合物，即海南巴豆素A‒C（1‒3），以及七种已知类似物（4 - 10）。通过光谱数据分析确定了这些化合物的结构。体外细胞毒性试验表明，化合物1 - 3对HL - 60细胞系表现出较强活性，IC值分别为0.47、0.58和1.27 μM。