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超声检查在发展中国家诊断肾母细胞瘤中的作用

The Role of Ultrasonography forDiagnosing Wilms Tumor in Developing Country.

作者信息

Rahmani Aulia, Sari Nur Melani, Indriasari Vita

机构信息

Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.

Departement of Pediatrics, Hematology & Oncology Division, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin Hospital, Bandung, Indonesia.

出版信息

Int J Hematol Oncol Stem Cell Res. 2021 Jul 1;15(3):145-151. doi: 10.18502/ijhoscr.v15i3.6844.

Abstract

Overall five-year survival rate of Wilm's Tumor (WT) in developing countries is still poor. Delayed diagnosis is one of the contributing factors, whereas early diagnosis is an important thing for the outcome. It is caused by the WT burden in developing countries that was not comparable with the number of facilities for diagnosis and treatment. Ultrasonography (USG) is the mandatory first-line imaging modality in children with a suspected abdominal mass and an overall sensitivity of 76%. Additionally, it can be found in many health facilities at a lower cost, quick, non-invasive, and carries no risk of radiation. Therefore, the relationship between USG and histopathology should be measured. A cross-sectional study with an analytical approach was performed in pediatric (0 untill 18 year of age) renal malignancy and neuroblastoma that admitted to Dr. Hasan Sadikin Hospital, Bandung between 2015-2018. Data were collected from medical records. Statistical analyses using Fisher exact test were done to determine the significance of the relationship between USG and histopathology. Forty-three samples were obtained based on inclusion criteria, such as WT (n=33), neuroblastoma (n=6), renal clear cell carcinoma (n=2) and no specific type of renal malignancy (n=2). Fisher exact test revealed no-significant relationship between USG and histopathology with p-value > 0.05 There is no significant relationship between USG and histopathology. Therefore, centralized unity for USG interpretation is recommended.

摘要

发展中国家肾母细胞瘤(WT)的总体五年生存率仍然很低。诊断延迟是一个促成因素,而早期诊断对治疗结果很重要。这是由于发展中国家的肾母细胞瘤负担与诊断和治疗设施数量不匹配所致。超声检查(USG)是疑似腹部肿块儿童的强制性一线成像方式,总体敏感度为76%。此外,它在许多医疗机构都能找到,成本较低,快速、无创且无辐射风险。因此,应该衡量超声检查与组织病理学之间的关系。对2015年至2018年期间入住万隆哈桑·萨迪金博士医院的儿科(0至18岁)肾恶性肿瘤和神经母细胞瘤患者进行了一项采用分析方法的横断面研究。数据从医疗记录中收集。使用Fisher精确检验进行统计分析,以确定超声检查与组织病理学之间关系的显著性。根据纳入标准获得了43个样本,如肾母细胞瘤(n = 33)、神经母细胞瘤(n = 6)、肾透明细胞癌(n = 2)和无特定类型的肾恶性肿瘤(n = 2)。Fisher精确检验显示超声检查与组织病理学之间无显著关系,p值>0.05。超声检查与组织病理学之间没有显著关系。因此,建议对超声检查结果解读进行集中统一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9139/8748242/43eb77361cce/IJHOSCR-15-145-g001.jpg

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