Baroudi Ihsan, Alakhras Ola, Douri Thaer, Alkhani Nedal
Faculty of medicine, University of Hama, Hama, Syria.
Department of Dermatology, Al Assad Medical Center, Hama, Syria.
Oxf Med Case Reports. 2022 Jan 24;2022(1):omab141. doi: 10.1093/omcr/omab141. eCollection 2022 Jan.
Aplasia cutis congenita (ACC) is a rare congenital defect described by the absence of skin and occasionally subcutaneous tissues or bone. The management of ACC varies depending on the lesion size, location and associated abnormalities. Small lesions often heal spontaneously, whereas larger lesions are significant and usually associated with additional anomalies in other organs. This paper reports three cases, which describe large lesions of ACC, presented with other abnormalities (Adams-Oliver syndrome, intestinal obstruction and heart defect). Particular attention should be paid to the patient with large lesions of ACC to investigate more congenital anomalies.
先天性皮肤发育不全（ACC）是一种罕见的先天性缺陷，其特征为皮肤缺失，偶尔伴有皮下组织或骨骼缺失。ACC的治疗方法因病变大小、位置及相关异常情况而异。小病变通常可自行愈合，而大病变则较为严重，通常还伴有其他器官的额外异常。本文报告了三例ACC大病变病例，这些病例伴有其他异常情况（亚当斯-奥利弗综合征、肠梗阻和心脏缺陷）。对于ACC大病变患者，应特别注意检查是否存在更多先天性异常。
