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人疱疹病毒8阳性弥漫性大B细胞淋巴瘤累及心脏：1例人类免疫缺陷病毒患者的罕见表现

Cardiac Involvement by Human Herpesvirus 8-Positive Diffuse Large B-Cell Lymphoma: An Unusual Presentation in a Patient with Human Immunodeficiency Virus.

作者信息

Fenu Elena M, Beaty Michael W, O'Neill Tiffany E, O'Neill Stacey S

机构信息

Atrium Wake Forest Baptist Health, Department of Pathology, Winston-Salem, NC, USA.

出版信息

Case Rep Pathol. 2022 Jan 17;2022:1298121. doi: 10.1155/2022/1298121. eCollection 2022.

DOI:10.1155/2022/1298121
PMID:35083089
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8786529/
Abstract

Human immunodeficiency virus (HIV) infection predisposes patients to the development of lymphomas, both due to immune suppression and coinfection with viruses with oncogenic potential. Coinfection with human herpesvirus 8 (HHV8) in particular has been associated with the development of aggressive lymphomas, including primary effusion lymphoma and diffuse large B-cell lymphoma (DLBCL). Herein, we report an unusual case of HHV8-positive DLBCL with extensive cardiac involvement which was diagnosed at autopsy in a patient with long-standing untreated HIV infection.

摘要

人类免疫缺陷病毒（HIV）感染使患者易患淋巴瘤，这是由于免疫抑制以及与具有致癌潜力的病毒共同感染所致。特别是与人类疱疹病毒8型（HHV8）共同感染，已被证实与侵袭性淋巴瘤的发生有关，包括原发性渗出性淋巴瘤和弥漫性大B细胞淋巴瘤（DLBCL）。在此，我们报告一例HHV8阳性的DLBCL罕见病例，该病例有广泛的心脏受累，在一名长期未接受治疗的HIV感染患者尸检时被诊断出来。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6b/8786529/5b6f7e5c3814/CRIPA2022-1298121.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6b/8786529/18db4aeaecd9/CRIPA2022-1298121.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6b/8786529/2500f07ed1b4/CRIPA2022-1298121.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6b/8786529/3275ca9c0eda/CRIPA2022-1298121.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6b/8786529/5b6f7e5c3814/CRIPA2022-1298121.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6b/8786529/18db4aeaecd9/CRIPA2022-1298121.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6b/8786529/2500f07ed1b4/CRIPA2022-1298121.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6b/8786529/3275ca9c0eda/CRIPA2022-1298121.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c6b/8786529/5b6f7e5c3814/CRIPA2022-1298121.004.jpg

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