Wang Weiqi, Wang Xinyue, Liu Lin, Liu Zengjiao, Han Tianshu, Sun Changhao, Yang Xue
National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, People's Republic of China.
Obesity (Silver Spring). 2022 Feb;30(2):515-523. doi: 10.1002/oby.23343.
The aims of this study were to examine the effects of tryptophan consumption on obesity and type 2 diabetes (T2D) risk and whether sleep duration mediates these effects.
Overall, data of 7,908 participants were obtained from the China Health and Nutrition Survey (1997-2011). A total of 6,373 and 4,398 participants who reported sleep duration and had blood samples, respectively, were incorporated into subgroup analyses. Multivariate Cox regression models were used to assess the associations between tertiles of tryptophan intake with obesity and T2D. General linear regression models were used to evaluate the effect of tryptophan on sleep time and plasma biomarkers.
Dietary tryptophan was significantly associated with decreased risk of obesity and T2D risk (hazard ratio : 0.602 [95% CI: 0.500-0.724]; 0.693 [95% CI: 0.565-0.850]). Sleep duration was significantly higher, and hemoglobin A1c, total cholesterol, low-density lipoprotein cholesterol, and apolipoprotein B-100 (APO-B) were lower in the high tertile of tryptophan compared with the low tertile (p < 0.05). In addition, mediation effects on the associations of tryptophan intake with obesity and T2D risk were observed for sleep duration (estimated mediation percentage: 31.902% and 37.391%).
Dietary tryptophan showed advantageous effects on obesity and T2D risk. Furthermore, sleep duration potentially mediated for these effects.
本研究旨在探讨色氨酸摄入对肥胖和2型糖尿病（T2D）风险的影响，以及睡眠时间是否介导这些影响。
总体而言，7908名参与者的数据来自中国健康与营养调查（1997 - 2011年）。分别有6373名报告了睡眠时间且有血样的参与者和4398名有血样的参与者被纳入亚组分析。多变量Cox回归模型用于评估色氨酸摄入量三分位数与肥胖和T2D之间的关联。一般线性回归模型用于评估色氨酸对睡眠时间和血浆生物标志物的影响。
膳食色氨酸与肥胖风险和T2D风险降低显著相关（风险比：0.602 [95%置信区间：0.500 - 0.724]；0.693 [95%置信区间：0.565 - 0.850]）。与低三分位数相比，色氨酸高三分位数组的睡眠时间显著更长，糖化血红蛋白、总胆固醇、低密度脂蛋白胆固醇和载脂蛋白B - 100（APO - B）更低（p < 0.05）。此外，观察到睡眠时间对色氨酸摄入量与肥胖和T2D风险之间的关联有中介作用（估计中介百分比：31.902%和37.391%）。
膳食色氨酸对肥胖和T2D风险显示出有益影响。此外，睡眠时间可能介导了这些影响。
