The Stem Cells and Immune Cells Biomedical Techniques Integrated Engineering Laboratory of State and Regions, Cell Therapy Technology Transfer Medical Key Laboratory of Yunnan Province, Kunming Key Laboratory of Stem Cell and Regenerative Medicine, Basic Medical Laboratory, 920th Hospital of Joint Logistics Support Force, PLA, Kunming, Yunnan 650032, China.
Kunming Medical University, Kunming, Yunnan 650500, China.
Chin Med J (Engl). 2022 Apr 20;135(8):901-910. doi: 10.1097/CM9.0000000000001984.
As human life expectancy continues to increase and the birth rate continues to decline, the phenomenon of aging is becoming more prominent worldwide. Therefore, addressing the problems associated with global aging has become a current research focus. The main manifestations of human aging are structural degeneration and functional decline of aging tissues and organs, quality of life decline, decreased ability to resist diseases, and high incidence rates of a variety of senile degenerative diseases. Thus far, no ideal treatments have been found. Stem cell (SC) therapies have broad application prospects in the field of regenerative medicine due to the inherent biological characteristics of SCs, such as their plasticity, self-renewal, and multidirectional differentiation potential. Thus, SCs could delay or even reverse aging. This manuscript reviews the causes of human aging, the biological characteristics of SCs, and research progress on age reversal.
随着人类预期寿命的不断延长和出生率的持续下降，老龄化现象在全球范围内变得更加突出。因此，解决与全球老龄化相关的问题已成为当前的研究重点。人类衰老的主要表现为衰老组织和器官的结构退化和功能下降、生活质量下降、疾病抵抗力下降以及各种老年退行性疾病的发病率升高。到目前为止，还没有找到理想的治疗方法。由于干细胞（SC）具有可塑性、自我更新和多向分化潜能等固有生物学特性，其在再生医学领域具有广阔的应用前景。因此，SC 可以延缓甚至逆转衰老。本文综述了人类衰老的原因、SC 的生物学特性以及逆转衰老的研究进展。
