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ACS Chem Neurosci. 2024 Feb 7;15(3):408-446. doi: 10.1021/acschemneuro.3c00532. Epub 2024 Jan 12.
Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Multiple strategies aiming to promote healthy aging and extend the lifespan have been developed including lifestyle adjustments, medical treatments, and social programs. A multitude of antiaging medicines and remedies have also been explored. Here, we use data from the CAS Content Collection to analyze the publication landscape of recent research related to antiaging strategies and treatments. We review the recent advances and delineate trends in research headway of antiaging knowledge and practice across time, geography, and development pipelines. We further assess the state-of-the-art antiaging approaches and explore their correlations with age-related diseases. The landscape of antiaging drugs has been outlined and explored. Well-recognized and novel, currently evaluated antiaging agents have also been summarized. Finally, we review clinical applications of antiaging products with their development pipelines. The objective of this review is to summarize current knowledge on preventive strategies and treatment remedies in the field of aging, to outline challenges and evaluate growth opportunities, in order to further efforts to solve the problems that remain.
衰老是指生理机能逐渐丧失和细胞损伤的积累，导致功能恶化和易患疾病。抗衰老研究在整个文明史上有着悠久的历史，人们付出了很多努力来理解和预防衰老的影响。已经开发出多种旨在促进健康衰老和延长寿命的策略，包括生活方式的调整、医疗治疗和社会项目。还探索了许多抗衰老药物和疗法。在这里，我们使用 CAS Content Collection 的数据来分析与抗衰老策略和治疗相关的最新研究的出版格局。我们回顾了最近的进展，并描绘了随着时间、地理和研发管道的推移，抗衰老知识和实践的研究进展趋势。我们进一步评估了最先进的抗衰老方法，并探讨了它们与与年龄相关的疾病的相关性。概述和探讨了抗衰老药物的格局。总结了目前评估中的公认和新颖的、目前评估中的抗衰老药物。最后，我们回顾了抗衰老产品的临床应用及其研发管道。本综述的目的是总结衰老领域的预防策略和治疗方法的现有知识，概述挑战并评估增长机会，以进一步努力解决仍然存在的问题。
