Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands.
Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Int J Antimicrob Agents. 2022 Mar;59(3):106538. doi: 10.1016/j.ijantimicag.2022.106538. Epub 2022 Jan 26.
Multinational surveillance programmes for methicillin-resistant Staphylococcus aureus (MRSA) are dependent on national structures for data collection. This study aimed to capture the diversity of national MRSA surveillance programmes and to propose a framework for harmonisation of MRSA surveillance. The International Society of Antimicrobial Chemotherapy (ISAC) MRSA Working Group conducted a structured survey on MRSA surveillance programmes and organised a webinar to discuss the programmes' strengths and challenges as well as guidelines for harmonisation. Completed surveys represented 24 MRSA surveillance programmes in 16 countries. Several countries reported separate epidemiological and microbiological surveillance. Informing clinicians and national policy-makers were the most common purposes of surveillance. Surveillance of bloodstream infections (BSIs) was present in all programmes. Other invasive infections were often included. Three countries reported active surveillance of MRSA carriage. Methodology and reporting of antimicrobial susceptibility, virulence factors, molecular genotyping and epidemiological metadata varied greatly. Current MRSA surveillance programmes rely upon heterogeneous data collection systems, which hampers international epidemiological monitoring and research. To harmonise MRSA surveillance, we suggest improving the integration of microbiological and epidemiological data, implementation of central biobanks for MRSA isolate collection, and inclusion of a representative sample of skin and soft-tissue infection cases in addition to all BSI cases.
耐甲氧西林金黄色葡萄球菌（MRSA）的跨国监测计划依赖于国家数据收集结构。本研究旨在捕捉国家 MRSA 监测计划的多样性，并提出一个 MRSA 监测协调框架。国际抗菌化疗学会（ISAC）MRSA 工作组对 MRSA 监测计划进行了结构化调查，并组织了一次网络研讨会，讨论了这些计划的优势和挑战，以及协调的指导方针。已完成的调查代表了 16 个国家的 24 个 MRSA 监测计划。一些国家报告了单独的流行病学和微生物监测。为临床医生和国家政策制定者提供信息是监测的最常见目的。所有计划都监测血流感染（BSI）。其他侵袭性感染通常也包括在内。三个国家报告了对 MRSA 定植的主动监测。抗菌药物敏感性、毒力因子、分子基因分型和流行病学元数据的方法和报告差异很大。当前的 MRSA 监测计划依赖于异构的数据收集系统，这阻碍了国际流行病学监测和研究。为了协调 MRSA 监测，我们建议改善微生物学和流行病学数据的整合，实施用于收集 MRSA 分离株的中央生物库，并纳入皮肤和软组织感染病例的代表性样本，除所有 BSI 病例外。
