妊娠期间母体钩虫感染导致胎儿宫内生长受限。
Impaired Intrauterine Growth in the Context of Maternal Hookworm Infection During Gestation.
机构信息
Center for International Health Research, Rhode Island Hospital, Providence, Rhode Island, USA.
Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.
出版信息
J Infect Dis. 2022 May 16;225(10):1856-1860. doi: 10.1093/infdis/jiac025.
Abstract
Hookworm infection is associated with poor nutritional outcomes, anemia, and impaired cognitive performance. We examined the association between maternal hookworm infection and birth outcomes in a cohort of women in Leyte, Philippines. We observed poor intrauterine growth characteristics associated with maternal hookworm only among male offspring, with lower birth weight, head circumference, and placental surface area. Male neonates also had higher insulin-like growth factor 2 (IGF-2) and lower adiponectin in cord blood. These data intriguingly suggest nutritional impacts of maternal hookworm infection during pregnancy may be divergent based on sex of the offspring.
摘要
钩虫感染与营养不良、贫血和认知能力受损有关。我们在菲律宾莱特的一组女性中研究了母体钩虫感染与生育结果之间的关系。我们发现，只有男性后代与母体钩虫有关的宫内生长特征较差，表现为出生体重、头围和胎盘表面积较低。男婴的脐血中胰岛素样生长因子 2（IGF-2）水平较高，脂联素水平较低。这些数据令人好奇地表明，母体钩虫感染在怀孕期间对营养的影响可能因后代的性别而不同。
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