McKittrick Noah D, Vu David M, Malhotra Indu, King Charles H, Mutuku Francis, LaBeaud A Desiree
Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Division of Infectious Diseases, Department of Pediatrics, Lucille Packard Children's Hospital at Stanford School of Medicine, Stanford, California, USA.
Clin Vaccine Immunol. 2017 Jun 5;24(6). doi: 10.1128/CVI.00039-17. Print 2017 Jun.
Many factors can influence maternal placental antibody transfer to the fetus, which confers important immune protection to the newborn infant. However, little is known about the effect of maternal parasitic infection on placental antibody transfer. To investigate this, we selected from a parent study of 576 pregnant Kenyan women four groups of women with term deliveries (≥37 weeks), including uninfected women ( = 30) and women with solo infections with malaria ( = 30), hookworm ( = 30), or schistosomiasis ( = 10). Maternal plasma at delivery and infant cord blood were tested via multiplex fluorescent bead assay for IgG against 10 pneumococcal serotypes (PnPs 1, 4, 5, 6B, 7F, 9V, 14, 18C, 19F, and 23F), diphtheria toxoid, and type B. Infants born to mothers with prenatal malaria, hookworm, or infections were associated with a significantly reduced ratio of maternal to infant cord blood antibody concentration for serotypes 1, 4, 5, 6B, 7F, 9V, and 18C compared to infants of uninfected mothers. Anti-diphtheria toxoid and anti- type B IgG ratios were not significantly different among infection groups. Prenatal parasitic infections decrease the transfer of maternal IgG antibodies to infants for several serotypes of .
许多因素会影响母体胎盘抗体向胎儿的转移，这为新生儿提供了重要的免疫保护。然而，关于母体寄生虫感染对胎盘抗体转移的影响却知之甚少。为了对此进行研究，我们从一项针对576名肯尼亚孕妇的母研究中，选取了四组足月分娩（≥37周）的女性，包括未感染女性（n = 30）以及分别感染疟疾（n = 30）、钩虫（n = 30）或血吸虫病（n = 10）的女性。通过多重荧光微球分析法检测分娩时的母体血浆和婴儿脐带血中针对10种肺炎球菌血清型（肺炎球菌血清型1、4、5、6B、7F、9V、14、18C、19F和23F）、白喉类毒素和B型流感嗜血杆菌的IgG。与未感染母亲的婴儿相比，产前感染疟疾、钩虫或血吸虫病母亲所生的婴儿，其血清型1、4、5、6B、7F、9V和18C的母体与婴儿脐带血抗体浓度比值显著降低。感染组之间抗白喉类毒素和抗B型流感嗜血杆菌IgG比值无显著差异。产前寄生虫感染会降低母体IgG抗体向婴儿体内几种肺炎球菌血清型的转移。
