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Androgens and COVID-19: exploring the role of testosterone replacement therapy.

作者信息

Punjani Nahid, Flannigan Ryan

机构信息

Department of Urology, Weill Cornell Medicine, New York, NY, USA.

Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

出版信息

Int J Impot Res. 2022 Nov;34(7):649-651. doi: 10.1038/s41443-021-00524-6. Epub 2022 Jan 30.

DOI:10.1038/s41443-021-00524-6
PMID:35094017
Abstract
摘要

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The Complex Interplay between Serum Testosterone and the Clinical Course of Coronavirus Disease 19 Pandemic: A Systematic Review of Clinical and Preclinical Evidence.血清睾酮与新型冠状病毒肺炎大流行临床进程之间的复杂相互作用：临床及临床前证据的系统评价
World J Mens Health. 2023 Jul;41(3):466-481. doi: 10.5534/wjmh.220143. Epub 2023 Jan 3.
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Use of Antiandrogens as Therapeutic Agents in COVID-19 Patients.

本文引用的文献

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Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19.循环性激素与 COVID-19 患者炎症和疾病严重程度的关联。
JAMA Netw Open. 2021 May 3;4(5):e2111398. doi: 10.1001/jamanetworkopen.2021.11398.
2
The impact of SARS-CoV-2 and COVID-19 on male reproduction and men's health.SARS-CoV-2 和 COVID-19 对男性生殖和男性健康的影响。
Fertil Steril. 2021 Apr;115(4):813-823. doi: 10.1016/j.fertnstert.2020.12.033. Epub 2021 Jan 1.
3
Role of testosterone in COVID-19 patients - A double-edged sword?
在 COVID-19 患者中使用抗雄激素作为治疗药物。
Viruses. 2022 Dec 7;14(12):2728. doi: 10.3390/v14122728.
4
SARS-CoV-2 infection and multi-organ system damage: A review.SARS-CoV-2 感染与多器官系统损伤：综述。
Biomol Biomed. 2023 Feb 1;23(1):37-52. doi: 10.17305/bjbms.2022.7762.
睾酮在 COVID-19 患者中的作用——一把双刃剑？
Med Hypotheses. 2020 Nov;144:110287. doi: 10.1016/j.mehy.2020.110287. Epub 2020 Sep 17.
4
COVID-19 Infection in Men on Testosterone Replacement Therapy.COVID-19 感染与接受睾丸素替代疗法的男性
J Sex Med. 2021 Jan;18(1):215-218. doi: 10.1016/j.jsxm.2020.09.013. Epub 2020 Oct 9.
5
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.严重急性呼吸综合征冠状病毒2（SARS-CoV-2）进入因子与固有免疫基因一起在鼻上皮细胞中高表达。
Nat Med. 2020 May;26(5):681-687. doi: 10.1038/s41591-020-0868-6. Epub 2020 Apr 23.
6
COVID-19: From bench to bed side.新冠病毒病：从实验室到临床
Diabetes Metab Syndr. 2020 Jul-Aug;14(4):277-281. doi: 10.1016/j.dsx.2020.04.011. Epub 2020 Apr 9.
7
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）进入细胞依赖于 ACE2 和 TMPRSS2，可被一种临床验证的蛋白酶抑制剂所阻断。
Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5.
8
Testosterone replacement therapy.睾酮替代疗法。
Andrology. 2020 Nov;8(6):1551-1566. doi: 10.1111/andr.12774. Epub 2020 Mar 9.
9
Testosterone replacement therapy and hospitalization rates in men with COPD.男性慢性阻塞性肺疾病患者的睾酮替代治疗与住院率。
Chron Respir Dis. 2019 Jan-Dec;16:1479972318793004. doi: 10.1177/1479972318793004. Epub 2018 Sep 11.
10
The relationship between circulating testosterone and inflammatory cytokines in men.男性循环睾酮与炎症细胞因子之间的关系。
Aging Male. 2019 Jun;22(2):129-140. doi: 10.1080/13685538.2018.1482487. Epub 2018 Jun 21.