Tachibana Hisao
Department of Neurology, Nishinomiya Kyoritsu Neurosurgical Hospital.
Rinsho Shinkeigaku. 2022 Feb 19;62(2):105-111. doi: 10.5692/clinicalneurol.cn-001698. Epub 2022 Jan 31.
Migraine is a common and often disabling disease with a prominent genetic basis. There are many comorbidities associated with migraine which have been identified as risk factors for progression to chronic migraine. Each of these has its own genetic load and shares some common characteristics with migraine. The identification of migraine comorbidities may help clarify common underlying genetic and biological mechanisms of diseases. The treatment of migraine should involve a multifaceted approach, aimed at identifying and reducing possible risk and comorbidity factors. This may prevent the evolution toward a chronic form and then toward pharmacological resistance.
偏头痛是一种常见且往往会导致功能障碍的疾病，具有显著的遗传基础。有许多与偏头痛相关的合并症已被确定为进展为慢性偏头痛的风险因素。这些合并症中的每一种都有其自身的遗传负荷，并与偏头痛有一些共同特征。偏头痛合并症的识别可能有助于阐明疾病常见的潜在遗传和生物学机制。偏头痛的治疗应采用多方面的方法，旨在识别和减少可能的风险和合并症因素。这可能会防止其演变为慢性形式，进而防止出现药物抵抗。
