Jadhav Toyaja, Prasad Shashi Shekhar, Guleria Bhupesh, Tevatia Manvir Singh, Guleria Prerna
Command Hospital (Southern Command), Department of Pathology, Pune, Maharashtra, India.
Command Hospital (Southern Command), Department of Medical Oncology, Malignant Diseases Treatment Center, Pune, Maharashtra, India.
Autops Case Rep. 2022 Jan 13;12:e2021352. doi: 10.4322/acr.2021.352. eCollection 2022.
Solid Papillary Carcinoma (SPC) of the breast is a rare tumor with an incidence of less than 1%, mainly affecting elderly females. It is morphologically characterized by well-defined nodules with low-grade nuclear features associated with fibrovascular cores and shows neuroendocrine differentiation. SPC can be in-situ or invasive but has a favorable prognosis. It is a morphological mimicker of some pre-malignant conditions leading to its frequent misdiagnosis. An appropriate immunohistochemical (IHC) panel workup helps in distinguishing this tumor from its various morphological mimics. In this report, we present one such case of SPC with a small focus of invasion, reviewing the literature.
乳腺实性乳头状癌(SPC)是一种罕见肿瘤,发病率低于1%,主要影响老年女性。其形态学特征为边界清晰的结节,具有与纤维血管轴心相关的低级别核特征,并显示神经内分泌分化。SPC可以是原位癌或浸润性癌,但预后良好。它在形态上可模仿一些癌前病变,导致其经常被误诊。适当的免疫组织化学(IHC)检测有助于将这种肿瘤与其各种形态学模仿病变区分开来。在本报告中,我们呈现了一例伴有小灶浸润的SPC病例,并复习相关文献。