Auger Nathalie, Marcoux Sophie, Bégin Philippe, Lewin Antoine, Lee Ga Eun, Healy-Profitós Jessica, Luu Thuy Mai
University of Montreal Hospital Research Center, Montreal, Quebec, Canada.
National Institute of Public Health of Quebec, Montreal, Quebec, Canada.
Cancer. 2022 Apr 15;128(8):1684-1691. doi: 10.1002/cncr.34115. Epub 2022 Jan 31.
Health outcomes of children in families affected by cancer are poorly understood. The authors assessed the risk of hospitalization in children who have a sibling with cancer.
This was a longitudinal cohort study in which 1600 children who had a sibling with cancer were matched to 32,000 children who had unaffected siblings in Quebec, Canada, from 2006 to 2020. The exposure of interest was having a sibling with cancer. Outcomes included hospitalization for pneumonia, asthma, fracture, and other morbidities any time after the sibling was diagnosed with cancer. The children were followed over time, and Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the impact of having a sibling with cancer on the risk of hospitalization before age 14 years, adjusted for patient characteristics.
Children who had a sibling with cancer had an increased risk of hospitalization compared with unaffected children (HR, 1.15; 95% CI, 1.02-1.29). Conditions associated with a greater risk of hospitalization included pneumonia, hemangioma, other skin conditions, sleep apnea, and inflammatory bowel disease. The risk of hospitalization was greatest for children whose older sibling had cancer (HR, 1.16; 95% CI, 1.01-1.32) and for children whose sibling had hematopoietic cancer (HR, 1.22; 95% CI, 1.01-1.48).
Children who have a sibling with cancer are at risk of hospitalization for conditions such as pneumonia, inflammatory bowel disease, and other morbidities. Families affected by childhood cancer may benefit from additional support to facilitate care for all children in the family.
Little is known about the health of children who have a brother or sister with cancer. The authors studied the types of hospitalization experienced by children who have siblings with cancer. The results indicated that having a sibling with cancer increased the chance of being hospitalized for pneumonia and other conditions that could have been preventable. The results also indicated that children who had an older sibling with cancer or a sibling with blood cancer had a greater chance of being hospitalized. The findings highlight the importance of providing timely care for children in families affected by childhood cancer.
受癌症影响家庭中儿童的健康状况鲜为人知。作者评估了有患癌兄弟姐妹的儿童的住院风险。
这是一项纵向队列研究，2006年至2020年期间，在加拿大魁北克，将1600名有患癌兄弟姐妹的儿童与32000名有未患癌兄弟姐妹的儿童进行匹配。感兴趣的暴露因素是有患癌的兄弟姐妹。结局包括在其兄弟姐妹被诊断患有癌症后的任何时间因肺炎、哮喘、骨折和其他疾病住院。对这些儿童进行长期随访，并使用Cox比例风险模型估计有患癌兄弟姐妹对14岁前住院风险的影响的风险比（HR）和95%置信区间（CI），并根据患者特征进行调整。
与未受影响的儿童相比，有患癌兄弟姐妹的儿童住院风险增加（HR，1.15；95%CI，1.02 - 1.29）。与住院风险增加相关的疾病包括肺炎、血管瘤、其他皮肤病、睡眠呼吸暂停和炎症性肠病。年龄较大的兄弟姐妹患癌的儿童（HR，1.16；95%CI，1.01 - 1.32）以及兄弟姐妹患造血系统癌症的儿童（HR，1.22；95%CI，1.01 - 1.48）住院风险最高。
有患癌兄弟姐妹的儿童有因肺炎、炎症性肠病和其他疾病住院的风险。受儿童癌症影响的家庭可能会从额外的支持中受益，以便利对家庭中所有儿童的照料。
对于有患癌兄弟姐妹的儿童的健康状况知之甚少。作者研究了有患癌兄弟姐妹的儿童所经历的住院类型。结果表明，有患癌兄弟姐妹会增加因肺炎和其他可能可预防的疾病住院的几率。结果还表明，有年龄较大的患癌兄弟姐妹或患血癌兄弟姐妹的儿童住院几率更高。这些发现凸显了为受儿童癌症影响家庭中的儿童提供及时照料的重要性。
