University of Montreal Hospital Research Centre, Montreal, Quebec, Canada; Institut national de santé publique du Québec, Montreal, Quebec, Canada; Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.
University of Montreal Hospital Research Centre, Montreal, Quebec, Canada; Institut national de santé publique du Québec, Montreal, Quebec, Canada.
Ann Epidemiol. 2024 Jun;94:27-32. doi: 10.1016/j.annepidem.2024.04.005. Epub 2024 Apr 16.
We assessed the risk of congenital anomalies in children who have a sibling with cancer.
We performed a matched cohort study of children born between 2006 and 2022 in Quebec. The exposure was having a sibling with cancer. Exposed children were matched to unexposed children based on sex, number of siblings, birth order, and year. The outcome included heart defects, orofacial clefts, and other anomalies. Using conditional logistic regression, we estimated odds ratios (OR) and 95 % confidence intervals (CI) for the association between having a sibling with cancer and the likelihood of having a congenital anomaly.
A total of 2403 children who had a sibling with cancer were matched to 240,257 unexposed children. Congenital anomalies were more frequent in children who had a sibling with cancer compared with unexposed children (10.3 % vs 8.9 %). Overall, having a sibling with cancer was only weakly associated with congenital anomalies (OR 1.18, 95 % CI 1.04-1.35). Exposed children tended to have greater odds of polydactyly/syndactyly (OR 1.89, 95 % CI 1.11-3.21) and urinary defects (OR 1.50, 95 % CI 1.09-2.08) compared with unexposed children.
Children who have a sibling with cancer have an only weakly elevated risk of congenital anomalies.
评估有癌症患儿的同胞罹患先天性畸形的风险。
我们对 2006 年至 2022 年期间在魁北克出生的儿童进行了一项匹配队列研究。暴露因素为有癌症患儿的同胞。根据性别、兄弟姐妹数量、出生顺序和年份，将暴露儿童与未暴露儿童进行匹配。结局包括心脏缺陷、口腔裂和其他畸形。采用条件逻辑回归，我们估计了有癌症患儿的同胞与罹患先天性畸形的可能性之间的关联的比值比（OR）和 95%置信区间（CI）。
共有 2403 名有癌症患儿的同胞与 240257 名未暴露儿童相匹配。与未暴露儿童相比，有癌症患儿的同胞罹患先天性畸形的频率更高（10.3% vs. 8.9%）。总体而言，有癌症患儿的同胞与先天性畸形仅存在微弱关联（OR 1.18，95%CI 1.04-1.35）。与未暴露儿童相比，暴露儿童更有可能出现多指/并指畸形（OR 1.89，95%CI 1.11-3.21）和泌尿缺陷（OR 1.50，95%CI 1.09-2.08）。
有癌症患儿的同胞罹患先天性畸形的风险仅略有升高。
