Department of Dermatology, Yenikent State Hospital, Sakarya, Turkey.
Department of Dermatology, Sakarya University Medical School, Sakarya, Turkey.
Int J Dermatol. 2022 Aug;61(8):988-994. doi: 10.1111/ijd.16054. Epub 2022 Jan 31.
Chronic urticaria is a disorder characterized by itchy erythematous plaques with edema lasting 6 weeks or more. The prevalence is 1%, and two thirds of these cases are "chronic spontaneous urticaria (CSU)." Drugs, food, infections, and systemic diseases may be etiologic factors for CSU, although it may be idiopathic.
The aim of this study was to compare the diversity and distribution of the intestinal microbiome in CSU patients with that of healthy individuals. The hypothesis was to determine the probable association of intestinal microbiome with CSU.
This study was conducted in Sakarya University Training and Research Hospital, Department of Dermatology. In this study, 20 CSU patients and 10 healthy volunteers were included. Stool samples were collected from all participants. 16S RNA sequencing and bioinformatic analysis were performed after isolation of DNA isolation from all samples.
Diversity in microorganisms, stool pH averages, Bristol scores, and the ratio of Firmicutes/Bacteroidetes were the significant changes between the two groups.
Due to high cost involved in microbiota studies, only a limited number of patients and volunteers participated.
The alteration in the intestinal microbiota (dysbiosis) may be an essential factor for CSU development and may explain idiopathic cases.
慢性荨麻疹是一种以瘙痒性红斑伴水肿持续 6 周或以上为特征的疾病。其患病率为 1%，其中三分之二为“慢性自发性荨麻疹（CSU）”。药物、食物、感染和系统性疾病可能是 CSU 的病因，但也可能是特发性的。
本研究旨在比较 CSU 患者与健康个体的肠道微生物组的多样性和分布。假设是确定肠道微生物组与 CSU 之间可能的关联。
本研究在萨卡里亚大学培训与研究医院皮肤科进行。本研究纳入了 20 名 CSU 患者和 10 名健康志愿者。从所有参与者中收集粪便样本。从所有样本中分离 DNA 后，进行 16S RNA 测序和生物信息学分析。
两组间微生物多样性、粪便 pH 平均值、布里斯托尔评分和厚壁菌门/拟杆菌门比值存在显著差异。
由于微生物组研究费用较高，只有有限数量的患者和志愿者参与。
肠道微生物组（失调）的改变可能是 CSU 发展的一个重要因素，并可能解释特发性病例。
