Department of Anaesthesiology Intensive Care, S.B.Ü. Tepecik Training and Research Hospital, İzmir, Turkey.
Department of Infectious Diseases and Clinical Microbiology, S.B.Ü. Tepecik Training and Research Hospital, İzmir, Turkey.
Anaesthesiol Intensive Ther. 2021;53(5):398-402. doi: 10.5114/ait.2021.111551.
We aimed to investigate the clinical features and mortality of critically ill patients treated with convalescent plasma for COVID-19 in the intensive care unit (ICU).
We retrospectively collected clinical and laboratory data of COVID-19 patients treated in the ICU. The patients were divided into two groups: those who received convalescent plasma and those who did not. We evaluated changes in the laboratory parameters and PaO2/FiO2 of the patients in the convalescent plasma group on days 0, 7, and 14.
A total of 188 patients were included, 89 of whom received convalescent plasma. There were no significant differences in length of hospitalization [median: 17 vs. 16 days, P = 0.13] or 28-day mortality between the two groups (59% vs. 65%, P = 0.38). The ICU stay of patients who received convalescent plasma was longer (P = 0.001). The dynamics of the laboratory parameters of 44 patients in the convalescent plasma group, who were still in intensive care on the 14th day, were analysed. There was no differences in CRP or PaO2/FiO2 on day 0, 7 or 14 (P = 0.12; P = 0.10, respectively).
Convalescent plasma treatment was not associated with shorter hospitalisation or lower mortality in patients diagnosed with COVID-19. However, the ICU stay was longer in patients who received convalescent plasma.
本研究旨在探讨重症监护病房（ICU）中 COVID-19 危重症患者接受恢复期血浆治疗的临床特征和死亡率。
我们回顾性收集了 ICU 中 COVID-19 患者的临床和实验室数据。患者分为两组：接受恢复期血浆治疗组和未接受治疗组。我们评估了恢复期血浆组患者在第 0、7 和 14 天的实验室参数和 PaO2/FiO2 的变化。
共纳入 188 例患者，其中 89 例接受了恢复期血浆治疗。两组患者的住院时间[中位数：17 天比 16 天，P = 0.13]或 28 天死亡率[59%比 65%，P = 0.38]均无显著差异。接受恢复期血浆治疗的患者 ICU 住院时间更长（P = 0.001）。对仍在第 14 天接受重症监护的 44 例恢复期血浆组患者的实验室参数动态进行分析。第 0、7 和 14 天的 CRP 或 PaO2/FiO2 无差异（P = 0.12；P = 0.10）。
恢复期血浆治疗与 COVID-19 患者的住院时间缩短或死亡率降低无关。然而，接受恢复期血浆治疗的患者 ICU 住院时间更长。
