Faculty of Medicine, "Lucian Blaga" University of Sibiu, Sibiu, Romania.
County Clinical Emergency Hospital of Sibiu, Sibiu, Romania.
In Vivo. 2022 May-Jun;36(3):1342-1348. doi: 10.21873/invivo.12836.
BACKGROUND/AIM: Convalescent plasma collected from COVID-19 survivors contains antibodies against receptor binding domains with potent antiviral activity. The use of this therapy for COVID-19 is still under investigation, as the pathophysiological and immunological mechanisms responsible for the evolution of the disease have not been fully identified.
In this retrospective observational study, we included all patients with a confirmed SARS-Cov-2 infection based on positive RT-PCR testing, who received convalescent plasma treatment in addition to standard therapy, between 17.05.2020 and 27.11.2020, following hospitalization in the Anaesthesia and Intensive Care Unit of the Sibiu County Emergency Clinical Hospital, Romania.
Convalescent plasma therapy of patients with SARS-Cov-2 infection and severe forms of the disease (requiring only high-flow oxygen therapy or non-invasive ventilation) significantly improved inflammatory markers (CRP, fibrinogen) and ventilatory parameters (SaO2, paO2, paO2/FiO2) reducing the need of supplemental oxygen delivery (p<0.05). Other factors that had a significant influence on the outcome were age and comorbidity.
Inflammatory markers and ventilatory parameters were significantly improved and the need of supplemental oxygen delivery was reduced in COVID-19 patients treated with convalescent plasma.
背景/目的：从 COVID-19 幸存者中采集的恢复期血浆含有针对受体结合域的抗体，具有强大的抗病毒活性。由于尚未完全确定导致疾病演变的病理生理和免疫机制，因此该疗法在 COVID-19 中的应用仍在研究中。
在这项回顾性观察研究中，我们纳入了所有基于 RT-PCR 检测呈阳性的确诊 SARS-CoV-2 感染患者，这些患者在 2020 年 5 月 17 日至 11 月 27 日期间在罗马尼亚锡比乌县急症临床医院的麻醉和重症监护病房住院期间，除了标准治疗外，还接受了恢复期血浆治疗。
恢复期血浆疗法可显著改善 SARS-CoV-2 感染和严重疾病（仅需要高流量氧疗或无创通气）患者的炎症标志物（CRP、纤维蛋白原）和通气参数（SaO2、paO2、paO2/FiO2），减少了对补充氧气输送的需求（p<0.05）。对结果有显著影响的其他因素是年龄和合并症。
在接受恢复期血浆治疗的 COVID-19 患者中，炎症标志物和通气参数得到了显著改善，并且对补充氧气输送的需求减少了。
