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评估血清肌酸激酶同工酶-MM 水平作为急诊医院工作人员职业性肌肉骨骼损伤的生物标志物。

Assessment of serum CK-MM level as a bioindicator for work-related musculoskeletal injuries among Emergency hospital workers.

机构信息

Department of Occupational and Environmental Medicine, Faculty of Medicine, 63527Cairo University, Egypt.

Department of Clinical and Chemical Pathology, Faculty of Medicine, 63527Cairo University, Egypt.

出版信息

Toxicol Ind Health. 2022 Jan;38(1):11-18. doi: 10.1177/07482337211042727.

DOI:10.1177/07482337211042727
PMID:35100895
Abstract

Musculoskeletal disorders (MSDs) are considered a growing problem among healthcare personnel, especially service workers. The emergency room (ER) service workers are highly exposed to work-related risk factors which predispose them to MSDs. A cross-sectional study was performed on 78 ER workers. Full medical and occupational histories were taken. The Standardized Nordic Questionnaire (SNQ) was used for the assessment of musculoskeletal symptoms. Clinical examination was done with special emphasis on the locomotors system, and serum levels of muscle enzymes, including creatine kinase (CK) and creatine kinase isoenzyme (CK-MM), were measured. The study aims to detect the prevalence of occupational musculoskeletal disorders (MSDs) among ER workers at University hospitals, and assessment of CK-MM as a biomarker used in the early detection of MSDs. We found that 71.8% of the participants were complaining of musculoskeletal disorder in the last 7 days before the study, while only 34.6% were complaining of musculoskeletal disorder in the last 12 months before the study. The knee joint was the most commonly affected site in the past 7 days, by 39.7%. On the other hand, the highest prevalent disorder in the last 12 months was for the ankle joint (17.9%) with significantly high levels of serum CK-MM. In conclusion, musculoskeletal injuries are a common complaint among healthcare occupations, especially among ER service workers that need regular health education and ergonomic training programs. Monitoring of serum CK-MM level with cut-off value 90 ng\ml could be used as a novel approach for the early detection of work-related musculoskeletal disorders.

摘要

肌肉骨骼疾病(MSD)被认为是医疗保健人员中日益严重的问题,尤其是服务工作者。急诊室(ER)工作人员高度暴露于与工作相关的危险因素,使他们易患 MSD。对 78 名急诊室工作人员进行了横断面研究。采集了完整的医疗和职业史。使用标准化北欧问卷(SNQ)评估肌肉骨骼症状。临床检查特别强调运动系统,测量血清肌肉酶水平,包括肌酸激酶(CK)和肌酸激酶同工酶(CK-MM)。本研究旨在检测大学医院急诊室工作人员职业性肌肉骨骼疾病(MSD)的患病率,并评估 CK-MM 作为早期检测 MSD 的生物标志物。我们发现,71.8%的参与者在研究前的最后 7 天抱怨肌肉骨骼疾病,而只有 34.6%的参与者在研究前的最后 12 个月抱怨肌肉骨骼疾病。在过去的 7 天内,膝关节是最常受影响的部位,占 39.7%。另一方面,在过去的 12 个月中,发病率最高的疾病是踝关节(17.9%),其血清 CK-MM 水平显著升高。总之,肌肉骨骼损伤是医疗保健职业中常见的抱怨,尤其是急诊服务工作者,他们需要定期进行健康教育和人体工程学培训计划。监测血清 CK-MM 水平(截断值为 90ng/ml)可作为早期发现与工作相关的肌肉骨骼疾病的新方法。

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