Department of Occupational Health, School of Public Health, 48435Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pharmacology and Toxicology, School of Pharmacy, 108917Shiraz University of Medical Sciences, Shiraz, Iran.
Toxicol Ind Health. 2022 Jan;38(1):29-40. doi: 10.1177/07482337211055132.
The cement industry is one of the main world industries with exposure to a wide range of hazardous chemical and physical occupational agents that may increase free radicals and lead to disease. The aim of this study was to evaluate oxidative stress, biochemical markers, and psychological parameters among cement plant workers. In this cross-sectional study, 40 workers exposed to cement and 40 office employees were selected as the exposed and non-exposed groups, respectively. Exposure to cement dust, silica, and noise were, respectively, assessed using the NIOSH 0600, NIOSH 7601, and noise dosimetry methods. Oxidative stress biomarkers including malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), total antioxidant capacity (TAC), and biochemical parameters were measured in the serum of all participants. Depression, anxiety, and stress were assessed by the Depression Anxiety Stress Scales (DASS-21) questionnaire. The results demonstrated that the level of MDA as a marker of oxidative stress was significantly higher in the exposed group. The level of antioxidant enzymes including SOD and CAT were also significantly higher in the exposed group. The level of TAC was lower in the exposed group, but the difference was not statistically significant. The levels of alkaline phosphatase (ALP), aspartate transaminase (AST), and the scores of depression and stress were also significantly higher in the exposed group. According to our results, noise, cement dust, and silica exposure were associated with oxidative stress, and this may be one of the mechanisms in which they adversely affect liver function and mental health.
水泥行业是全球主要行业之一，工人接触到广泛的有害化学和物理职业因素，这些因素可能会增加自由基，导致疾病。本研究旨在评估水泥厂工人的氧化应激、生化标志物和心理参数。在这项横断面研究中，分别选择了 40 名接触水泥和 40 名办公室员工作为暴露组和非暴露组。使用 NIOSH 0600、NIOSH 7601 和噪声剂量测定方法分别评估水泥粉尘、二氧化硅和噪声的暴露情况。测量了所有参与者血清中的氧化应激生物标志物，包括丙二醛（MDA）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、总抗氧化能力（TAC）和生化参数。使用抑郁焦虑压力量表（DASS-21）问卷评估抑郁、焦虑和压力。结果表明，作为氧化应激标志物的 MDA 水平在暴露组中显著升高。暴露组中抗氧化酶 SOD 和 CAT 的水平也显著升高。暴露组中 TAC 的水平较低，但差异无统计学意义。碱性磷酸酶（ALP）、天冬氨酸转氨酶（AST）以及抑郁和压力评分在暴露组中也显著升高。根据我们的结果，噪声、水泥粉尘和二氧化硅暴露与氧化应激有关，这可能是它们对肝功能和心理健康产生不利影响的机制之一。
