Pournourmohammadi S, Khazaeli P, Eslamizad S, Tajvar A, Mohammadirad A, Abdollahi M
Faculty of Pharmacy, and Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Hum Exp Toxicol. 2008 Jun;27(6):463-9. doi: 10.1177/0960327108094956.
The cement industry is considered as a major pollution problem because of dust and particulate matter emitted at various steps of cement production. In the present study, volunteer male workers from a cement factory were studied for oxidative and nitrosative stress biomarkers in relation to their serum levels of aluminum (Al) and chromium (Cr). The subjects were divided into two groups of direct and indirect exposure. Subject who worked in production steps were considered as direct exposure group, and those who worked in administration building were considered as indirect exposure group. For comparison, healthy subjects at the same age and socioeconomic status were tested as a control group. Serum levels of lipid peroxidation (LP), total antioxidant capacity (TAC), total thiol molecules (TTM), and nitric oxide (NO) as well as Al and Cr were measured. The results indicated a significant increase in Al (P = 0.001) and Cr (P = 0.009) levels in direct-exposed workers in comparison to healthy control group. Further, a significant increase in Al (P = 0.002) and Cr (P = 0.009) levels was observed in direct-exposed workers as compared to indirect-exposed one. Serum levels of TTM and TAC were significantly lower in both direct- and indirect-exposed groups in comparison to healthy control group (P = 0.00). Serum TTM and TAC were significantly lower in direct-exposed workers as compared to indirect-exposed ones (P = 0.00 and P = 0.024, respectively). There was no significant difference on the level of LP and NO among groups. A correlation was found between serum level of Cr, TAC, and platelets between direct- and indirect-exposed groups (P < 0.05). Further correlation was found among serum level of Cr and those of TTM, platelets, and chronic disease (P < 0.05). Chronic disease had a significant influence adjusted to other predictor variables on the post-shift values of Al (P < 0.05). Although plasma levels of Al and Cr were found in normal ranges, analyses confirm their role in impairment of TMM and TAC.
由于水泥生产各环节会排放粉尘和颗粒物，水泥行业被视为一个主要的污染问题。在本研究中，对一家水泥厂的男性志愿工人进行了研究，以探讨与他们血清中铝（Al）和铬（Cr）水平相关的氧化应激和亚硝化应激生物标志物。受试者被分为直接暴露组和间接暴露组。在生产环节工作的受试者被视为直接暴露组，在行政楼工作的受试者被视为间接暴露组。为作比较，选取了年龄和社会经济地位相同的健康受试者作为对照组进行检测。测量了血清中的脂质过氧化（LP）、总抗氧化能力（TAC）、总硫醇分子（TTM）、一氧化氮（NO）以及Al和Cr的水平。结果表明，与健康对照组相比，直接暴露工人的Al（P = 0.001）和Cr（P = 0.009）水平显著升高。此外，与间接暴露工人相比，直接暴露工人的Al（P = 0.002）和Cr（P = 0.009）水平也显著升高。与健康对照组相比，直接暴露组和间接暴露组的血清TTM和TAC水平均显著降低（P = 0.00）。与间接暴露工人相比，直接暴露工人的血清TTM和TAC水平显著更低（分别为P = 0.00和P = 0.024）。各组之间LP和NO水平无显著差异。在直接暴露组和间接暴露组之间，发现血清Cr水平、TAC水平与血小板之间存在相关性（P < 0.05）。进一步发现血清Cr水平与TTM、血小板水平以及慢性病之间存在相关性（P < 0.05）。在对其他预测变量进行调整后，慢性病对轮班后Al的值有显著影响（P < 0.05）。尽管血浆中Al和Cr的水平在正常范围内，但分析证实了它们在损害TMM和TAC方面的作用。
