Babiloni Claudio, Del Percio Claudio, Lizio Roberta, Lopez Susanna, Pennica Alfredo, Roma Paolo, Correr Valentina, Cucciolla Federica, Toma Ginevra, Soricelli Andrea, Di Campli Francesco, Aceti Antonio, Teti Elisabetta, Sarmati Loredana, Crocetti Gloria, Ferri Raffaele, Lorenzo Ivan, Galli Massimo, Negri Cristina, Angarano Gioacchino, Saracino Annalisa, Lepore Luciana, Di Pietro Massimo, Fusco Francesco Maria, Vullo Vincenzo, D'Ettorre Gabriella, Pagliano Pasquale, Di Flumeri Giusy, Celesia Benedetto Maurizio, Gentilini Cacciola Elio, Di Perri Giovanni, Calcagno Andrea, Stocchi Fabrizio, Ferracuti Stefano, Onorati Paolo, Andreoni Massimo, Noce Giuseppe
Department of Physiology and Pharmacology "Erspamer", Sapienza University of Rome, Rome, Italy; Hospital San Raffaele Cassino, Cassino (FR), Italy.
Department of Physiology and Pharmacology "Erspamer", Sapienza University of Rome, Rome, Italy.
Brain Res Bull. 2022 Apr;181:129-143. doi: 10.1016/j.brainresbull.2022.01.015. Epub 2022 Jan 29.
Previous evidence showed abnormal parietal sources of resting-state electroencephalographic (EEG) delta (< 4 Hz) and alpha (8-12 Hz) rhythms in treatment-Naïve HIV (Naïve HIV) subjects, as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis that these local abnormalities may be related to functional cortical dysconnectivity as an oscillatory brain network disorder. The present EEG database regarded 128 Naïve HIV and 60 Healthy subjects. The eLORETA freeware estimated lagged linear EEG source connectivity (LLC). The area under receiver operating characteristic (AUROC) curve indexed the accuracy in the classification between Healthy and HIV individuals. Parietal intrahemispheric LLC solutions in alpha sources were abnormally lower in the Naïve HIV than in the control group. Furthermore, those abnormalities were greater in the Naïve HIV subgroup with executive and visuospatial deficits than the Naïve HIV subgroup with normal cognition. AUROC curves of those LLC solutions exhibited moderate/good accuracies (0.75-0.88) in the discrimination between the Naïve HIV individuals with executive and visuospatial deficits vs. Naïve HIV individuals with normal cognition and control individuals. In quiet wakefulness, Naïve HIV subjects showed clinically relevant abnormalities in parietal alpha source connectivity. HIV may alter a parietal "hub" oscillating at the alpha frequency in quiet wakefulness as a brain network disorder.
