Department of Physiology and Pharmacology "Vittorio Erspamer", University of Rome "La Sapienza", Rome, Italy; Institute for Research and Medical Care, IRCCS San Raffaele Pisana, Rome, Italy.
Department of Integrated Imaging, IRCCS SDN, Naples, Italy.
Neurobiol Aging. 2018 May;65:18-40. doi: 10.1016/j.neurobiolaging.2017.12.023. Epub 2017 Dec 30.
Previous evidence showed abnormal posterior sources of resting-state delta (<4 Hz) and alpha (8-12 Hz) rhythms in patients with Alzheimer's disease with dementia (ADD), Parkinson's disease with dementia (PDD), and Lewy body dementia (DLB), as cortical neural synchronization markers in quiet wakefulness. Here, we tested the hypothesis of additional abnormalities in functional cortical connectivity computed in those sources, in ADD, considered as a "disconnection cortical syndrome", in comparison with PDD and DLB. Resting-state eyes-closed electroencephalographic (rsEEG) rhythms had been collected in 42 ADD, 42 PDD, 34 DLB, and 40 normal healthy older (Nold) participants. Exact low-resolution brain electromagnetic tomography (eLORETA) freeware estimated the functional lagged linear connectivity (LLC) from rsEEG cortical sources in delta, theta, alpha, beta, and gamma bands. The area under receiver operating characteristic (AUROC) curve indexed the classification accuracy between Nold and diseased individuals (only values >0.7 were considered). Interhemispheric and intrahemispheric LLCs in widespread delta sources were abnormally higher in the ADD group and, unexpectedly, normal in DLB and PDD groups. Intrahemispheric LLC was reduced in widespread alpha sources dramatically in ADD, markedly in DLB, and moderately in PDD group. Furthermore, the interhemispheric LLC in widespread alpha sources showed lower values in ADD and DLB than PDD groups. At the individual level, AUROC curves of LLC in alpha sources exhibited better classification accuracies for the discrimination of ADD versus Nold individuals (0.84) than for DLB versus Nold participants (0.78) and PDD versus Nold participants (0.75). Functional cortical connectivity markers in delta and alpha sources suggest a more compromised neurophysiological reserve in ADD than DLB, at both group and individual levels.
先前的证据表明，阿尔茨海默病伴痴呆（ADD）、帕金森病伴痴呆（PDD）和路易体痴呆（DLB）患者静息状态下的后源 delta（<4 Hz）和 alpha（8-12 Hz）节律异常，作为安静觉醒时皮质神经同步的标志物。在这里，我们测试了在 ADD 中存在额外功能皮质连接异常的假设，将其视为“脱连接皮质综合征”，并与 PDD 和 DLB 进行比较。42 名 ADD、42 名 PDD、34 名 DLB 和 40 名正常健康老年人（Nold）参与者进行了静息状态闭眼脑电图（rsEEG）节律采集。精确低分辨率脑电磁层析成像（eLORETA）免费软件估计了 delta、theta、alpha、beta 和 gamma 频段 rsEEG 皮质源的功能滞后线性连接（LLC）。接收器操作特性（AUROC）曲线下面积索引了 Nold 和患病个体之间的分类准确性（仅考虑>0.7 的值）。在 ADD 组中，广泛 delta 源的半球间和半球内 LLC 异常升高，而在 DLB 和 PDD 组中则正常。ADD 组广泛 alpha 源的半球内 LLC 显著降低，DLB 组明显降低，PDD 组中度降低。此外，ADD 和 DLB 组广泛 alpha 源的半球间 LLC 值低于 PDD 组。在个体水平上，alpha 源 LLC 的 AUROC 曲线在区分 ADD 与 Nold 个体（0.84）方面的分类准确性优于 DLB 与 Nold 参与者（0.78）和 PDD 与 Nold 参与者（0.75）。delta 和 alpha 源的功能皮质连接标志物表明，ADD 比 DLB 在组和个体水平上的神经生理储备更差。
