多靶点粪便 DNA 检测用于结直肠癌筛查的诊断准确性：系统评价和荟萃分析。
Diagnostic accuracy of multitarget stool DNA testing for colorectal cancer screening: A systematic review and meta-analysis.
机构信息
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
出版信息
Gastroenterol Hepatol. 2022 Dec;45(10):753-766. doi: 10.1016/j.gastrohep.2022.01.007. Epub 2022 Jan 31.
INTRODUCTION
This study aimed to collect and summarize test data and conduct a meta-analysis, with respect to the Multitarget Stool DNA test sensitivity and specificity, compared to colonoscopy.
MATERIAL AND METHODS
All manuscripts were screened for eligibility according to inclusion criteria. Participants were a normal population at an average risk of developing CRC. Intervention was Stool based and DNA panel tests compared with colonoscopy, and outcome was detection of CRC and any pre-cancerous lesions. Inter-study and inconsistency (using the I-squared test) were assessed.
RESULTS
Meta-analyses of the Mt-sDNA test showed a combined sensitivity of 89%, 51%, and 76% for the detection of CRC, advanced adenoma (AA), and combined CRC and AA, respectively. The overall specificity was 91%, 89%, and 90% for the detection of CRC, AA, and combined CRC and AA, respectively.
CONCLUSION
Mt-sDNA had significantly acceptable diagnostic accuracy for CRC and AA diagnosis, but still has lower sensitivity and specificity than colonoscopy.
简介
本研究旨在收集和总结测试数据，并进行荟萃分析，比较多靶点粪便 DNA 检测与结肠镜检查的灵敏度和特异性。
材料与方法
根据纳入标准筛选所有符合条件的文献。研究对象为结直肠癌平均发病风险的普通人群。干预措施是基于粪便的 DNA 面板检测，并与结肠镜检查进行比较，结果是检测 CRC 和任何癌前病变。评估了研究间和不一致性（使用 I 平方检验）。
结果
Mt-sDNA 检测的荟萃分析显示，CRC、高级腺瘤（AA）和 CRC 和 AA 合并的检测灵敏度分别为 89%、51%和 76%。CRC、AA 和 CRC 和 AA 合并的检测总体特异性分别为 91%、89%和 90%。
结论
Mt-sDNA 对 CRC 和 AA 的诊断具有显著可接受的诊断准确性，但敏感性和特异性仍低于结肠镜检查。
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