二溴乙烷（DBE）与X射线联合作用对紫露草体细胞突变的诱导效应。

The combined effect of DBE and X-rays on the induction of somatic mutations in Tradescantia.

作者信息

Leenhouts H P, Sijsma M J, Cebulska-Wasilewska A, Chadwick K H

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Jan;49(1):109-19. doi: 10.1080/09553008514552281.

Abstract

The induction of somatic mutations in the stamen hair cells of Tradescantia KU 9 has been used to investigate the effects of combined exposure to 1,2-dibromoethane (DBE) and X-rays. At low radiation doses a synergistic interaction has been found between the two agents for both DBE exposure followed by acute X-rays and chronic simultaneous exposures. The synergism is discussed in terms of an interaction of single strand lesions in the DNA. It is concluded that although this type of interaction should not be too important for radiological protection, it could be of significance in evaluating the effects of chemicals at low exposure rates.

摘要

利用紫露草KU 9雄蕊毛细胞中体细胞突变的诱导来研究1,2 - 二溴乙烷（DBE）和X射线联合暴露的影响。在低辐射剂量下，对于先暴露于DBE后进行急性X射线照射以及慢性同时暴露这两种情况，均发现两种试剂之间存在协同相互作用。从DNA中单链损伤的相互作用角度对这种协同作用进行了讨论。得出的结论是，尽管这种相互作用类型对放射防护而言可能不太重要，但在评估低暴露率化学品的影响时可能具有重要意义。