卤代化合物对人细胞中白喉毒素抗性突变体的诱导作用。
Induction of diphtheria toxin-resistant mutants in human cells by halogenated compounds.
作者信息
Ferreri A M, Rocchi P, Capucci A, Prodi G
出版信息
J Cancer Res Clin Oncol. 1983;105(1):111-2. doi: 10.1007/BF00391843.
Abstract
The mutagenic power of 1,2-dichloroethane, 1,2-dibromoethane, 1,2-diiodoethane was tested in the human cell line, EUE. In our mutagenic system, based on selection against diphtheria toxin, the halogenated compounds, 1,2-dichloroethane and 1,2-dibromoethane revealed a strong mutagenic effect, whereas 1,2-diiodoethane was not mutagenic at a concentration allowing survival of 41%.
摘要
在人类细胞系EUE中测试了1,2 - 二氯乙烷、1,2 - 二溴乙烷和1,2 - 二碘乙烷的致突变能力。在我们基于抗白喉毒素筛选的致突变系统中，卤代化合物1,2 - 二氯乙烷和1,2 - 二溴乙烷显示出强烈的致突变作用，而1,2 - 二碘乙烷在允许41%存活率的浓度下没有致突变性。
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