Habti Merieme, Hubert Gervaise, Marzouki Monia, Piché Nelson
Pediatric Surgery, Université de Montréal, Montreal, CAN.
Pediatric Oncology, Centre Hospitalier Universitaire Sainte-Justine, Montreal, CAN.
Cureus. 2021 Dec 21;13(12):e20584. doi: 10.7759/cureus.20584. eCollection 2021 Dec.
Pleuropulmonary blastoma (PPB) is a rare pediatric cancer, and although there have been improvements in its treatment approach, recurrences retain a very poor prognosis. Here, we report a case of a 30-month-old female who survived recurrent PPB after undergoing surgery, adjuvant chemotherapy, intrapleural cisplatin infusion, and targeted therapy through whole exome sequencing (WES). Intrapleural cisplatin infusion and target therapy appear to be safe and can be considered in a multimodal approach for the management of recurrent PPB.
胸膜肺母细胞瘤（PPB）是一种罕见的儿童癌症，尽管其治疗方法已有改进，但复发后的预后仍然很差。在此，我们报告一例30个月大的女性病例，该患者在接受手术、辅助化疗、胸膜腔内顺铂灌注以及通过全外显子组测序（WES）进行靶向治疗后，复发性PPB存活下来。胸膜腔内顺铂灌注和靶向治疗似乎是安全的，可在复发性PPB的多模式治疗中予以考虑。
