Fowler J E
J Urol. 1986 Jan;135(1):22-5. doi: 10.1016/s0022-5347(17)45502-9.
Prompted by reports of tumor regression among patients with metastatic renal cell carcinoma treated by injection of an aggregated autologous or allogeneic tumor antigen with a nonspecific adjuvant, we studied the efficacy of this therapy in 23 patients. Following nephrectomy or excision of a metastatic lesion 16 patients were treated with an aggregated autologous tumor antigen combined with Candida albicans antigen. There were only 2 minimal responses. Seven patients judged unsuitable for an operation were treated with an aggregated allogeneic antigen. There were no objective responses. We conclude that these treatment regimens have minimal activity against metastatic renal cell carcinoma.
受转移性肾细胞癌患者通过注射聚集的自体或同种异体肿瘤抗原与非特异性佐剂治疗后肿瘤消退报告的启发，我们研究了该疗法对23例患者的疗效。在肾切除术或转移性病灶切除术后，16例患者接受了聚集的自体肿瘤抗原与白色念珠菌抗原联合治疗。仅有2例轻微反应。7例被判定不适合手术的患者接受了聚集的同种异体抗原治疗。无客观反应。我们得出结论，这些治疗方案对转移性肾细胞癌的活性极小。
