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多发性骨髓瘤中急性脑病的罕见病因

An Uncommon Cause of Acute Encephalopathy in Multiple Myeloma.

作者信息

Al Zeyoudi Jawaher, Al Naqbi Aisha, Kashiwagi Deanne, Siddiqui Mustaqeem

机构信息

Internal Medicine, Sheikh Khalifa Medical City, Abu Dhabi, ARE.

Internal Medicine, Sheikh Shakbout Medical City, Abu Dhabi, ARE.

出版信息

Cureus. 2021 Dec 22;13(12):e20605. doi: 10.7759/cureus.20605. eCollection 2021 Dec.

DOI:10.7759/cureus.20605
PMID:35103181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8781650/
Abstract

Multiple myeloma commonly presents with bone pain, pathological fractures, hypercalcemia, anemia, and acute kidney injury. Altered mental status due to multiple myeloma is generally attributed to uremia, hypercalcemia, and hyperviscosity. In this report, we present a rare case of altered mental status due to high serum ammonia levels in a patient with advanced multiple myeloma and with no liver dysfunction.

摘要

多发性骨髓瘤通常表现为骨痛、病理性骨折、高钙血症、贫血和急性肾损伤。多发性骨髓瘤所致的精神状态改变一般归因于尿毒症、高钙血症和血液黏稠度增加。在本报告中,我们呈现了1例晚期多发性骨髓瘤患者因血清氨水平升高导致精神状态改变的罕见病例,该患者并无肝功能障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6852/8781650/8455105cb825/cureus-0013-00000020605-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6852/8781650/8455105cb825/cureus-0013-00000020605-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6852/8781650/8455105cb825/cureus-0013-00000020605-i01.jpg

相似文献

1
An Uncommon Cause of Acute Encephalopathy in Multiple Myeloma.多发性骨髓瘤中急性脑病的罕见病因
Cureus. 2021 Dec 22;13(12):e20605. doi: 10.7759/cureus.20605. eCollection 2021 Dec.
2
Hyperammonemia: an unusual presenting feature of multiple myeloma.高氨血症:多发性骨髓瘤的一种不寻常的临床表现。
Indian J Med Sci. 2005 Jan;59(1):24-7.
3
Hyperammonemic Encephalopathy in Multiple Myeloma: A Case Report.多发性骨髓瘤中的高氨血症性脑病:一例报告
Cureus. 2023 Jan 10;15(1):e33626. doi: 10.7759/cureus.33626. eCollection 2023 Jan.
4
[Hyperammonemic encephalopathy as the presenting feature of a relapsing multiple myeloma].[高氨血症性脑病作为复发性多发性骨髓瘤的首发特征]
Rev Med Interne. 2016 Aug;37(8):567-9. doi: 10.1016/j.revmed.2015.11.003. Epub 2015 Dec 8.
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Multiple Myeloma-Induced Hyperammonemic Encephalopathy.多发性骨髓瘤所致高氨血症性脑病
J Hematol. 2017 Mar;6(1):29-31. doi: 10.14740/jh322e. Epub 2017 Mar 21.
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[Clinical significance of a multiple myeloma cell line, derived from a case associated with hyperammonemia].[源自一例伴有高氨血症病例的多发性骨髓瘤细胞系的临床意义]
Rinsho Ketsueki. 2000 Nov;41(11):1220-5.
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An Unusual Cause of Altered Mental Status in Multiple Myeloma: An Extraosseous Manifestation.多发性骨髓瘤患者精神状态改变的不寻常原因:一种骨外表现。
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Viscous Vengeance: A Case Report of Hyperviscosity Syndrome in IgA Lambda Multiple Myeloma.黏性复仇:一例 IgA λ 型多发性骨髓瘤高黏滞血症综合征的病例报告
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Hyperammonemic Encephalopathy: A Unique Presentation of Multiple Myeloma.高氨血症性脑病:多发性骨髓瘤的一种独特表现。
Cureus. 2021 Jan 19;13(1):e12781. doi: 10.7759/cureus.12781.
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[A case of hyperammonemia presented in a patient with multiple myeloma].[1例多发性骨髓瘤患者出现高氨血症的病例]
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本文引用的文献

1
Multiple myeloma epidemiology and survival: A unique malignancy.多发性骨髓瘤的流行病学与生存率:一种独特的恶性肿瘤。
Semin Oncol. 2016 Dec;43(6):676-681. doi: 10.1053/j.seminoncol.2016.11.004. Epub 2016 Nov 10.
2
Multiple myeloma-induced hyperammonemic encephalopathy: an entity associated with high in-patient mortality.多发性骨髓瘤相关性高氨血症性脑病:一种与高住院死亡率相关的疾病实体。
Leuk Res. 2013 Oct;37(10):1229-32. doi: 10.1016/j.leukres.2013.07.014. Epub 2013 Aug 6.
3
Noncirrhotic hyperammonaemic encephalopathy.非肝硬化性高氨血症性脑病。
Liver Int. 2011 Oct;31(9):1259-70. doi: 10.1111/j.1478-3231.2011.02550.x. Epub 2011 Jun 21.
4
NCCN clinical practice guidelines in oncology: multiple myeloma.美国国立综合癌症网络(NCCN)肿瘤学临床实践指南:多发性骨髓瘤
J Natl Compr Canc Netw. 2009 Oct;7(9):908-42. doi: 10.6004/jnccn.2009.0061.
5
Multiple myeloma and hyperammonemic encephalopathy: review of 27 cases.多发性骨髓瘤与高氨血症性脑病:27例病例回顾
Clin Lymphoma Myeloma. 2008 Dec;8(6):363-9. doi: 10.3816/CLM.2008.n.054.
6
In vitro excess ammonia production in human myeloma cell lines.人骨髓瘤细胞系体外过量氨生成
Leukemia. 1998 Jul;12(7):1149-58. doi: 10.1038/sj.leu.2401077.