Costa J, Delacrétaz F
Pathol Annu. 1986;21 Pt 1:159-71.
We propose that the term midline granuloma be used to designate a syndrome and not specific forms of disease. We present a classification and terminology that divides the entities previously grouped under "midline granuloma" into four main categories: Wegener's granulomatosis, idiopathic midline destructive disease, lymphomatoid granulomatosis, and angiocentric lymphoma. Except in the case of idiopathic midline destructive disease, which is exclusively limited to the upper respiratory tract, the other forms can be localized or disseminated. In most cases the histopathologic distinction between these forms can be reliably made and provides guidance for therapy.
我们建议使用“中线肉芽肿”这一术语来指代一种综合征，而非特定的疾病形式。我们提出一种分类和术语，将先前归为“中线肉芽肿”的实体分为四大类：韦格纳肉芽肿、特发性中线破坏性疾病、淋巴瘤样肉芽肿和血管中心性淋巴瘤。除特发性中线破坏性疾病仅局限于上呼吸道外，其他形式可为局限性或播散性。在大多数情况下，这些形式之间的组织病理学区分可以可靠地做出，并为治疗提供指导。
