Reversing type 1 diabetes with stem cell-derived islets: a step closer to the dream?
作者信息
Butler Peter C, Gale Edwin Am
机构信息
Larry Hillblom Islet Research Center, Department of Medicine, UCLA, Los Angeles, California, USA.
Diabetes and Metabolism, University of Bristol, Bristol, United Kingdom.
出版信息
J Clin Invest. 2022 Feb 1;132(3). doi: 10.1172/JCI158305.
Abstract
摘要
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J Clin Invest. 2022 Feb 1;132(3). doi: 10.1172/JCI158305.
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本文引用的文献
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Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device.在封装装置中植入干细胞衍生的胰腺内胚层细胞的 1 型糖尿病患者的胰岛素表达和 C 肽。
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Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive C-peptide in patients with type 1 diabetes.植入的多能干细胞衍生的胰腺内胚层细胞在 1 型糖尿病患者中分泌葡萄糖反应性 C 肽。
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Clinical pancreatic islet transplantation.临床胰腺胰岛移植。
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The majority of patients with long-duration type 1 diabetes are insulin microsecretors and have functioning beta cells.大多数长病程 1 型糖尿病患者都是胰岛素微量分泌者，且β细胞仍具有功能。
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Recruitment to a clinical trial improves glycemic control in patients with diabetes.招募患者参加临床试验可改善糖尿病患者的血糖控制。
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Changes in renal function after clinical islet transplantation: four-year observational study.临床胰岛移植后肾功能的变化：四年观察性研究。
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