Riesen Walter F
Diessenhofen.
Praxis (Bern 1994). 2022 Feb;110(2):86-88. doi: 10.1024/1661-8157/a003797.
Pleiotropic Effects of Statins - What Is Their Clinical Significance? Pleiotropic Effects of Statins - What Is Their Clinical Significance? Statins have several pleiotropic effects, such as anti-inflammation, anti-thrombotic effects, inhibition of smooth muscle cell proliferation and apoptosis, inhibition of migration and activation of macrophages. They increase blood glucose with the exception of pitavastatin. The clnical importance of the pleiotropic effects of statins however remains unclear. The lowering of Low Density Lipoprotein cholesterol (LDL-C) has similar effects on the reduction of cardiovascular effects no matter whether this reduction was obtained by statin or by non-statin therapy, indicating that the reduction in LDL-C per se is responsible for the beneficial effect. However, pleiotropic effects of statins might play a role with respect to microvascular events. The difference in pleiotropic effects between the different statins might be a basis for a patient-oriented statin therapy.
他汀类药物的多效性作用——其临床意义是什么？他汀类药物的多效性作用——其临床意义是什么？他汀类药物具有多种多效性作用，如抗炎、抗血栓形成作用、抑制平滑肌细胞增殖和凋亡、抑制巨噬细胞迁移和活化。除匹伐他汀外，它们会升高血糖。然而，他汀类药物多效性作用的临床重要性仍不明确。无论低密度脂蛋白胆固醇（LDL-C）的降低是通过他汀类药物还是非他汀类药物治疗实现的，其降低对心血管效应的降低具有相似作用，这表明LDL-C的降低本身是有益作用的原因。然而，他汀类药物的多效性作用可能在微血管事件方面发挥作用。不同他汀类药物之间多效性作用的差异可能是个体化他汀类药物治疗的基础。
