Department of Radiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Research Center of Clinical Medical Imaging, Anhui Province, Hefei 230032, China.
Cereb Cortex. 2022 Nov 9;32(22):5132-5144. doi: 10.1093/cercor/bhac003.
Neuronal oscillations within certain frequency bands are assumed to associate with specific neural processes and cognitive functions. To examine this hypothesis, transcriptome-neuroimaging spatial correlation analysis was applied to resting-state functional magnetic resonance imaging data from 793 healthy individuals and gene expression data from the Allen Human Brain Atlas. We found that expression measures of 336 genes were correlated with fractional amplitude of low-frequency fluctuations (fALFF) in the slow-4 band (0.027-0.073 Hz), whereas there were no expression-fALFF correlations for the other frequency bands. Furthermore, functional enrichment analyses showed that these slow-4 fALFF-related genes were mainly enriched for ion channel, synaptic function, and neuronal system as well as many neuropsychiatric disorders. Specific expression analyses demonstrated that these genes were specifically expressed in brain tissue, in neurons, and during the late stage of cortical development. Concurrently, the fALFF-related genes were linked to multiple behavioral domains, including dementia, attention, and emotion. In addition, these genes could construct a protein-protein interaction network supported by 30 hub genes. Our findings of a frequency-dependent genetic modulation of spontaneous neuronal activity may support the concept that neuronal oscillations within different frequency bands capture distinct neurobiological processes from the perspective of underlying molecular mechanisms.
特定频段的神经元振荡被认为与特定的神经过程和认知功能有关。为了检验这一假说，我们对 793 名健康个体的静息态功能磁共振成像数据和艾伦人类大脑图谱的基因表达数据进行了转录组-神经影像学空间相关分析。我们发现，336 个基因的表达水平与慢波 4 带（0.027-0.073 Hz）的低频波动（fALFF）呈正相关，而其他频段则没有表达与 fALFF 的相关性。此外，功能富集分析表明，这些与慢波 4 的 fALFF 相关的基因主要富集在离子通道、突触功能和神经元系统以及许多神经精神疾病中。特异性表达分析表明，这些基因在脑组织中特异性表达，在神经元中表达，并在皮质发育的晚期表达。同时，fALFF 相关基因与包括痴呆、注意力和情绪在内的多个行为领域相关。此外，这些基因可以构建一个由 30 个枢纽基因支持的蛋白质-蛋白质相互作用网络。我们发现自发神经元活动的频率依赖性遗传调节，这可能支持不同频率带的神经元振荡从潜在的分子机制角度捕获不同的神经生物学过程的概念。
