Screening of anti-cancerous potential of classical and modified modified with (nanodiamond) through FTIR & LC-MS analysis.

OBJECTIVES

is an ayurvedic medicine explicitly prescribed for the treatment of (cancer), whereas has the potential to promote cancer healing properties. Together, these two medicines provide multifunction benefits. This paper analyses the functional groups of modified with and compares it with the classically prepared . To identify the functional group, organic ligands, and active compounds present in samples of (CRR) and modified with (MRR) contributing to cancer alleviation by using Fourier transform infrared spectroscopy (FTIR) & LC-MS analysis.

METHODS

Classical (CRR), its ingredients, (SK); decoction of Linn. (PBD); Linn. (ASD); Linn. (BDD); Linn. (PLD); cow urine (GM), & similarly modified (MRR), its ingredients,  (HB); (SHR); water-soluble extract of Linn. (PBE); Linn. (ASE); Linn. (BDE); cow urine (GA); Linn. (PLE) were subjected to FTIR and LC-MS analysis.

RESULTS

Among all 15 samples studied, maximum numbers of peaks (21) were seen in MRR indicating a greater number of functional groups. Further, in MRR, a maximum peak in the double bond region is suggestive of its higher stability compared to CRR. Both the compound is preliminarily a mixture of the number of functional groups like; fluoro, methyl, amino, hydroxy, nitro, methylamino, carbonyl, and iodo groups, having known anti-proliferative activities. By the FT-IR analysis, the biologically active compounds in aqueous and methanol extract of CRR & MRR were identified that have anti-cancerous compounds. In the present study, a total of 40 major compounds like alkaloids, amino acid, carboxylic acid, Flavonoids, Nucleoside, Nucleotide, phenylpropanoid, Sphingosine, stilbenoid, sugar, phosphate, terpenoids, vitamin from aqueous & methanol extract of CRR & MRR were identified by LC-MS.

CONCLUSIONS

This research paper highlights the presence of different functional groups and bioactive compounds known to have anti-cancer activities. Thus, this review suggests future recommendations for the design and development of improved anticancer drugs with higher efficacy.