School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan.
Brain Research Institute, Niigata University, 757, Ichiban-cho, Asahimachidori, Chuo-ku, Niigata 951-8585, Japan.
Chem Commun (Camb). 2022 Feb 17;58(15):2576-2579. doi: 10.1039/d1cc07000b.
Curcumin derivatives B and N were developed as disaggregation agents of amyloid β (Aβ) fibrils. The detoxification provided by each compound at a concentration of 1 μM was observed in neuroblastoma cells. Furthermore, both compounds significantly rescued locomotion dysfunction in an Aβ-expressing model of Alzheimer's disease.
姜黄素衍生物 B 和 N 被开发为淀粉样 β (Aβ) 纤维的解聚剂。在浓度为 1 μM 的情况下，观察到每种化合物提供的解毒作用在神经母细胞瘤细胞中。此外，这两种化合物都能显著改善阿尔茨海默病的 Aβ 表达模型中的运动功能障碍。
