Garodia Prachi, Hegde Mangala, Kunnumakkara Ajaikumar B, Aggarwal Bharat B
Integrative Research Center, Miami, FL, USA.
Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Assam, India.
Integr Med Res. 2023 Sep;12(3):100968. doi: 10.1016/j.imr.2023.100968. Epub 2023 Jun 25.
Despite the extensive research in recent years, the current treatment modalities for neurological disorders are suboptimal. Curcumin, a polyphenol found in genus, has been shown to mitigate the pathophysiology and clinical sequalae involved in neuroinflammation and neurodegenerative diseases.
We searched PubMed database for relevant publications on curcumin and its uses in treating neurological diseases. We also reviewed relevant clinical trials which appeared on searching PubMed database using 'Curcumin and clinical trials'.
This review details the pleiotropic immunomodulatory functions and neuroprotective properties of curcumin, its derivatives and formulations in various preclinical and clinical investigations. The effects of curcumin on neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), brain tumors, epilepsy, Huntington's disorder (HD), ischemia, Parkinson's disease (PD), multiple sclerosis (MS), and traumatic brain injury (TBI) with a major focus on associated signalling pathways have been thoroughly discussed.
This review demonstrates curcumin can suppress spinal neuroinflammation by modulating diverse astroglia mediated cascades, ensuring the treatment of neurological disorders.
尽管近年来进行了广泛研究，但目前用于治疗神经疾病的方法仍不尽人意。姜黄素是姜黄属植物中的一种多酚，已被证明可减轻神经炎症和神经退行性疾病中涉及的病理生理学和临床后遗症。
我们在PubMed数据库中搜索了有关姜黄素及其在治疗神经疾病方面用途的相关出版物。我们还回顾了使用“姜黄素与临床试验”在PubMed数据库搜索时出现的相关临床试验。
本综述详细介绍了姜黄素及其衍生物和制剂在各种临床前和临床研究中的多效免疫调节功能和神经保护特性。已对姜黄素对神经退行性疾病如阿尔茨海默病（AD）、肌萎缩侧索硬化症（ALS）、脑肿瘤、癫痫、亨廷顿病（HD）、缺血、帕金森病（PD）、多发性硬化症（MS）和创伤性脑损伤（TBI）的影响进行了深入讨论，主要关注相关信号通路。
本综述表明姜黄素可通过调节多种星形胶质细胞介导的级联反应来抑制脊髓神经炎症，有望用于神经疾病的治疗。
