Institute of Advanced Cross-field Science and College of Life Science, Qingdao University, Qingdao, 266071, China.
School of Materials Science and Engineering, Suzhou University of Science and Technology, Suzhou, 215009, China.
Nanoscale. 2022 Feb 17;14(7):2686-2695. doi: 10.1039/d1nr08016d.
Bacterial infections have become a major problem threatening public health, and it is of great significance to treat wound infections in biological systems caused by bacteria. However, traditionally used bacteriostatic agents usually cause additional pollution. Herein a mushroom-shaped clean and Green BiFeO/g-CN composite is employed for the first time for photocatalytic antibacterial activity and for the further promotion of wound healing. The ratio between BiFeO and g-CN was delicately regulated to control the generated amount of ˙OH and ˙O by catalyzing the decomposition of hydrogen peroxide (HO) under illumination. Results show that 10%BFO/CN demonstrates the best performance for ˙OH and ˙O production, resulting in the highest antibacterial ability against and . In addition, the catalytic mechanism of BiFeO/g-CN towards antibacterial activity is disclosed by a combination of ESR monitoring and analysis of the Mott-Schottky diagram. Furthermore, experiments prove that 10%BFO/CN can effectively promote anti-infection and wound healing in nude mice. This work sheds deep scientific insight on the synergistic effect of photocatalysis and photo-Fenton degradation as well as their application in antibacterial and wound therapeutic activity.
细菌感染已成为威胁公众健康的主要问题，因此，治疗由细菌引起的生物体系中的伤口感染具有重要意义。然而，传统使用的抑菌剂通常会造成额外的污染。本文首次采用蘑菇状清洁环保的 BiFeO/g-CN 复合材料用于光催化抗菌活性，并进一步促进伤口愈合。通过控制光照下过氧化氢（HO）分解产生的˙OH 和 ˙O 的量，精细调节 BiFeO 和 g-CN 的比例。结果表明，10%BFO/CN 对 ˙OH 和 ˙O 的产生表现出最佳性能，对 和 表现出最高的抗菌能力。此外，通过电子顺磁共振（ESR）监测和 Mott-Schottky 图分析相结合，揭示了 BiFeO/g-CN 对抑菌活性的催化机制。进一步的活体实验证明，10%BFO/CN 可有效促进裸鼠的抗感染和伤口愈合。这项工作为光催化和光芬顿降解的协同效应及其在抗菌和伤口治疗活性中的应用提供了深入的科学见解。
