Jia Chenyang, Wu Fu-Gen
State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
BME Front. 2023 Jul 17;4:0021. doi: 10.34133/bmef.0021. eCollection 2023.
The wide and frequent use of antibiotics in the treatment of bacterial infection can cause the occurrence of multidrug-resistant bacteria, which becomes a serious health threat. Therefore, it is necessary to develop antibiotic-independent treatment modalities. Chemodynamic therapy (CDT) is defined as the approach employing Fenton and/or Fenton-like reactions for generating hydroxyl radical (•OH) that can kill target cells. Recently, CDT has been successfully employed for antibacterial applications. Apart from the common Fe-mediated CDT strategy, antibacterial CDT strategies mediated by other metal elements such as copper, manganese, cobalt, molybdenum, platinum, tungsten, nickel, silver, ruthenium, and zinc have also been proposed. Furthermore, different types of materials like nanomaterials and hydrogels can be adopted for constructing CDT-involved antibacterial platforms. Besides, CDT can introduce some toxic metal elements and then achieve synergistic antibacterial effects together with reactive oxygen species. Finally, CDT can be combined with other therapies such as starvation therapy, phototherapy, and sonodynamic therapy for achieving improved antibacterial performance. This review first summarizes the advancements in antibacterial CDT and then discusses the present limitations and future research directions in this field, hoping to promote the development of more effective materials and strategies for achieving potentiated CDT.
在细菌感染治疗中广泛且频繁地使用抗生素会导致多重耐药菌的出现，这对健康构成了严重威胁。因此，有必要开发不依赖抗生素的治疗方式。化学动力疗法（CDT）被定义为利用芬顿和/或类芬顿反应生成可杀死靶细胞的羟基自由基（•OH）的方法。最近，CDT已成功应用于抗菌领域。除了常见的铁介导的CDT策略外，还提出了由其他金属元素如铜、锰、钴、钼、铂、钨、镍、银、钌和锌介导的抗菌CDT策略。此外，可采用不同类型的材料如纳米材料和水凝胶来构建涉及CDT的抗菌平台。此外，CDT可引入一些有毒金属元素，然后与活性氧一起实现协同抗菌效果。最后，CDT可与其他疗法如饥饿疗法、光疗法和声动力疗法相结合，以实现更好的抗菌性能。本文综述首先总结了抗菌CDT的进展，然后讨论了该领域目前的局限性和未来的研究方向，希望能促进开发更有效的材料和策略以实现增强的CDT。
