Departamento de Gastroenterologia, Hospital de Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.
Departamento de Cirurgia Geral e Transplantes, Hospital Adventista Silvestre, Rio de Janeiro, RJ, Brasil.
Arq Bras Cir Dig. 2022 Jan 31;34(4):e1625. doi: 10.1590/0102-672020210002e1625. eCollection 2022.
Colorectal cancer (CRC) is the third most common neoplasm, and half of the patients with CRC develop liver metastasis. The best prognostic factor for colorectal liver metastasis (CRLM) is the possibility of performing a resection with free margins; however, most of them remain unresectable. The justification for performing liver transplantation (LT) in patients with CRLM regards an increase in the number of resectable patients by performing total hepatectomy. The aim of this study was to provide a Brazilian protocol for LT in patients with unresectable CRLM.
The protocol was carried out by two Brazilian institutions, which perform a large volume of resections and LTs, based on the study carried out at the University of Oslo. The elaboration of the protocol was conducted in four stages.
A protocol proposal for this disease is presented, which needs to be validated for clinical use.
The development of an LT protocol for unresectable CRLM aims to standardize the treatment and to enable a better evaluation of surgical results.
结直肠癌（CRC）是第三大常见肿瘤，一半的 CRC 患者会发生肝转移。结直肠肝转移（CRLM）的最佳预后因素是能否进行无切缘限制的切除术；然而，大多数患者仍无法切除。在 CRLM 患者中进行肝移植（LT）的理由是通过实施全肝切除术增加可切除患者的数量。本研究的目的是为巴西不可切除 CRLM 患者的 LT 提供一个方案。
该方案由两个巴西机构实施，这两个机构基于奥斯陆大学的研究进行了大量的切除术和 LT。方案的制定分为四个阶段进行。
提出了一种针对该疾病的方案建议，需要进行临床验证。
制定不可切除 CRLM 的 LT 方案旨在使治疗标准化，并能够更好地评估手术结果。
