Disease Vector Group, Department of Plant Protection Biology, Alnarp, Sweden.
J Chem Ecol. 2022 Apr;48(4):359-369. doi: 10.1007/s10886-021-01347-x. Epub 2022 Feb 2.
Host-derived repellents offer a novel way to reduce disease vector-host interactions, particularly for vectors and nuisance pests where commercial repellents are not available, e.g., Culicoides biting midges. By revising the criteria previously used to identify bioactive volatile organic compounds for Culicoides nubeculosus, we identify (E)-2-hexenal, (E)-2-heptenal, (E)-2-octenal, and (E)-2-nonenal to be differentially present in the headspace odour of cattle hair and to elicit antennal responses in this research model species. A blend of these unsaturated aldehydes elicited an aversive response in C. nubeculosus, as well as a repellent response in three disease vector mosquito species, Aedes aegypti, Culex quinquefasciatus and Anopheles coluzzii, a response that was stronger than that to the commercially available repellents tested (DEET, IR3535, PMD, icaridin, and d-allethrin). Culicoides nubeculosus was behaviourally indifferent to these commercially available repellents tested, except d-allethrin to which it was attracted. The identification of a host-derived repellent odour blend, which reduces the interaction between biting midges extends the array of tools to be used in integrated vector management of these and other disease vectors.
宿主源驱避剂为减少病媒与宿主的相互作用提供了一种新方法，特别是对于商业驱避剂不可用的病媒和滋扰害虫，例如致倦库蚊。通过修改先前用于鉴定致倦库蚊生物活性挥发性有机化合物的标准，我们确定（E）-2-己烯醛、（E）-2-庚烯醛、（E）-2-辛烯醛和（E）-2-壬烯醛在牛毛的头气味中存在差异，并在该研究模式物种中引起触角反应。这些不饱和醛的混合物在致倦库蚊中引起了厌恶反应，以及在三种病媒蚊种埃及伊蚊、三带喙库蚊和致倦库蚊中引起了驱避反应，这种反应比测试的商业上可用的驱避剂（避蚊胺、IR3535、PMD、派卡瑞丁和右旋烯丙菊酯）更强。致倦库蚊对这些商业上可用的驱避剂测试表现出行为上的漠不关心，除了右旋烯丙菊酯，它对其具有吸引力。宿主源驱避剂气味混合物的鉴定减少了吸血蠓的相互作用，扩展了用于这些和其他病媒综合管理的工具范围。
