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马尾综合征患者的经肛门肠道灌洗常规

Transanal irrigation bowel routine for people with Cauda Equina Syndrome.

作者信息

Ethans Karen, Smith Karen, Khandelwal Avni, Nankar Mayur, Shea Jessie, Casey Alan

机构信息

Section of Physical Medicine and Rehabilitation, University of Manitoba, Winnipeg, Canada.

Department of Physical Medicine and Rehabilitation, Queens University, Kingston, Canada.

出版信息

J Spinal Cord Med. 2024 Mar;47(2):263-269. doi: 10.1080/10790268.2021.2022371. Epub 2022 Feb 2.

Abstract

OBJECTIVE

Neurologic bowel incontinence and dysfunction are common with Cauda Equina Syndrome (CES). The study objective was to evaluate the efficacy of Peristeen Anal Irrigation System (PAIS) in people with CES.

DESIGN

Clinical Trial.

SETTING

Spinal Cord Rehabilitation outpatient clinic at the Health Sciences Centre in Winnipeg.

METHODS

Twelve participants with a mean age of 46.2 years (range 34-72 years, 4 females) with CES used PAIS bowel routine for 10 weeks.

OUTCOME MEASURES

Change in Neurogenic Bowel Dysfunction Score (NBD) over 10 weeks relative to baseline. Change in St. Mark's Fecal Incontinence score (SMFI), Cleveland Clinic Constipation score (CCC), and modified Rectal Surgeons Fecal Incontinence Quality of Life Score (QOL) at week 1, 2, 4, 6, 8 and 10 compared to baseline, and self-rating of bowel function at baseline and 10 weeks. Additionally, colonic transit times were assessed using the radioactive markers (Sitzmarks) method.

RESULTS

Ten participants completed the study. Post-intervention primary outcome NBD score improved ( < 0.01). Secondary outcomes also improved significantly, including SMFI ( < 0.01), CCC ( < 0.01), QOL ( < 0.01), self-rating of bowel function ( < 0.01), and transit time improved by 22% ( < 0.05).

CONCLUSION

Overall, a significant improvement was observed with the PAIS for both primary, as well as secondary outcome measures, without any significant adverse effects. As this non-pharmaceutical method of bowel management is effective and has the potential to improve symptoms of bowel dysfunction in people with CES, it should be considered for those in which traditional methods of managing neurogenic bowel fail.

摘要

目的

马尾综合征(CES)常伴有神经源性大便失禁和功能障碍。本研究的目的是评估佩里斯汀肛门冲洗系统(PAIS)对患有CES的患者的疗效。

设计

临床试验。

地点

温尼伯健康科学中心的脊髓康复门诊。

方法

12名平均年龄为46.2岁(年龄范围34 - 72岁,4名女性)的CES患者使用PAIS进行为期10周的肠道护理常规。

观察指标

与基线相比,10周内神经源性肠功能障碍评分(NBD)的变化。在第1、2、4、6、8和10周时,与基线相比,圣马克大便失禁评分(SMFI)、克利夫兰诊所便秘评分(CCC)和改良直肠外科医生大便失禁生活质量评分(QOL)的变化,以及基线和10周时的肠道功能自我评分。此外,使用放射性标记物( Sitzmarks)法评估结肠转运时间。

结果

10名参与者完成了研究。干预后主要观察指标NBD评分有所改善(<0.01)。次要观察指标也有显著改善,包括SMFI(<0.01)、CCC(<0.01)、QOL(<0.01)、肠道功能自我评分(<0.01),转运时间改善了22%(<0.05)。

结论

总体而言,PAIS在主要和次要观察指标方面均有显著改善,且无任何明显不良反应。由于这种非药物性肠道管理方法有效,并且有可能改善CES患者的肠道功能障碍症状,对于那些传统神经源性肠道管理方法无效的患者,应考虑使用该方法。

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