Nutrition Academic Area, Institute of Health Sciences, Universidad Autónoma del Estado de Hidalgo, Pachuca de Soto, Hidalgo.
Institute of Nutrition, Universidad de la Sierra Sur, Miahuatlán de Porfirio Díaz, Oaxaca. Mexico.
Gac Med Mex. 2021;157(6):599-603. doi: 10.24875/GMM.M21000623.
In Mexico, there is a syndemic in pregnant women, where the epidemic of obesity and chronic diseases coexists with that of coronavirus disease 2019 (COVID-19), which has been associated with a higher risk of maternal mortality.
To evaluate the association of comorbidities during pregnancy with maternal mortality from COVID-19 in Mexico.
SISVER COVID-19 databases and epidemiological surveillance reports on maternal mortality were used. Multivariate logistic regression models were used to evaluate the association of comorbidities with maternal deaths from COVID-19.
A total of 29,416 pregnant women were evaluated, out of which 39% were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); the risk of maternal mortality was 3.24 times higher (p < 0.01) for positive in comparison with negative women. COVID-19 is the leading cause of maternal death since July 2020 and explains more than 50% of total deaths in 2021. Chronic kidney disease (odds ratio [OR]: 4.11; p < 0.01) and diabetes (OR: 2.53; p < 0.01) were the two main comorbidities that were positively associated with maternal death from COVID-19.
Comorbidities during pregnancy that are possibly associated with an increase in the inflammatory response and an alteration of the immune response increase the risk of maternal death from COVID-19 in Mexican pregnant women.
在墨西哥，孕妇同时存在肥胖和慢性病流行以及 2019 年冠状病毒病（COVID-19）流行的综合征，这与产妇死亡率升高有关。
评估孕妇合并症与 COVID-19 导致的墨西哥产妇死亡的相关性。
使用 SISVER COVID-19 数据库和孕产妇死亡率流行病学监测报告。使用多变量逻辑回归模型评估合并症与 COVID-19 产妇死亡的相关性。
共评估了 29416 名孕妇，其中 39% 的孕妇 SARS-CoV-2 严重急性呼吸综合征冠状病毒 2 检测呈阳性；与阴性孕妇相比，阳性孕妇的产妇死亡风险高 3.24 倍（p<0.01）。自 2020 年 7 月以来，COVID-19 是导致产妇死亡的主要原因，占 2021 年总死亡人数的 50%以上。慢性肾脏病（优势比 [OR]：4.11；p<0.01）和糖尿病（OR：2.53；p<0.01）是与 COVID-19 导致产妇死亡相关的两个主要合并症。
可能与炎症反应增加和免疫反应改变相关的孕妇合并症增加了墨西哥孕妇 COVID-19 导致的产妇死亡风险。
