免疫衰老与新冠疫情时代的衰老相关疾病
Immune system aging and the aging-related diseases in the COVID-19 era.
机构信息
Department of Pathophysiology, Medical University of Gdańsk, Dębinki 7, 80-211, Gdańsk, Poland.
出版信息
Immunol Lett. 2022 Mar;243:19-27. doi: 10.1016/j.imlet.2022.01.005. Epub 2022 Jan 31.
The interest in the process of aging, and specifically in how aging affects the working of our immune system, has recently enormously grown among both specialists (immunologists and gerontologists) and representatives of other disciplines of health sciences. An obvious reason for this interest is the current pandemics of COVID-19, known to affect the elderly more than younger people. In this paper current knowledge about mechanisms and complex facets of human immune system aging is presented, stemming from the knowledge about the working of various parts of the immune system, and leading to understanding of immunological mechanisms of chronic, inflammatory, aging-related diseases and of COVID-19.
人们对衰老过程，特别是衰老如何影响我们免疫系统的工作，产生了浓厚的兴趣，这一兴趣在专家（免疫学家和老年病学家）和健康科学其他学科的代表中都与日俱增。这种兴趣的一个明显原因是当前 COVID-19 的大流行，众所周知，老年人比年轻人更容易受到影响。本文介绍了当前关于人类免疫系统衰老的机制和复杂方面的知识，这些知识源于对免疫系统各个部分的工作的了解，进而理解慢性、炎症、与衰老相关的疾病和 COVID-19 的免疫学机制。
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