核糖体失活蛋白的最新进展。

Ribosome-inactivating proteins up to date.

作者信息

Stirpe F, Barbieri L

出版信息

FEBS Lett. 1986 Jan 20;195(1-2):1-8. doi: 10.1016/0014-5793(86)80118-1.

Abstract

Ribosome-inactivating proteins (RIPs) from plants inactivate eukaryotic ribosomes, as far as studied by rendering their 60 S subunit unable to bind elongation factor 2. These proteins seem widely distributed and possibly ubiquitous in plants. They are either type 1, those consisting of a single polypeptide chain, or type 2 (ricin and related toxins), those consisting of two chains, one of which is a galactose-binding lectin. The literature on RIPs from 1982 has been reviewed with respect to the chemical and biological properties of RIPs, their use for the preparation of immunotoxins and new perspectives.

摘要

就目前的研究而言，植物中的核糖体失活蛋白（RIPs）可使真核生物核糖体失活，方法是使其60 S亚基无法结合延伸因子2。这些蛋白质似乎在植物中广泛分布，甚至可能普遍存在。它们要么是1型，即由单条多肽链组成，要么是2型（蓖麻毒素及相关毒素），即由两条链组成，其中一条是半乳糖结合凝集素。关于1982年以来RIPs的文献已就RIPs的化学和生物学特性、其在制备免疫毒素方面的应用以及新的研究前景进行了综述。