Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Invest Dermatol. 2022 May;142(5):1253-1255. doi: 10.1016/j.jid.2021.11.023. Epub 2022 Jan 31.
DNA methylation and demethylation function in the balance between cellular differentiation and cancer. Although the roles of DNA methyltransferases have been extensively explored in epidermal biology, ten-eleven translocation (TET) demethylase enzymes are poorly understood. In their new article in the Journal of Investigative Dermatology, Boudra et al. present evidence for a tumor-suppressive role of TET2 and its regulation of 5-hydroxymethylcytosine in the prevention of squamous cell carcinomas.
DNA 甲基化和去甲基化在细胞分化和癌症之间的平衡中发挥作用。尽管 DNA 甲基转移酶的作用在表皮生物学中得到了广泛的研究，但 ten-eleven translocation（TET）去甲基化酶的作用却知之甚少。在他们发表在《皮肤病学研究杂志》上的新文章中，Boudra 等人提出 TET2 具有肿瘤抑制作用，其通过调节 5-羟甲基胞嘧啶来预防鳞状细胞癌。
