Novella-Navarro Marta, Cabrera-Alarcón José Luis, Rosales-Alexander José Luis, González-Martín Jorge Juan, Carrión Ofelia, Peña Paloma García de la
Department of Rheumatology, Hospital Universitario Sanchinarro, Madrid, Spain.
Bioinformatic Unit, GENOXPHOS-group Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
Eur J Rheumatol. 2022 Jan;9(1):20-25. doi: 10.5152/eurjrheum.2021.20093.
To assess the prevalence of subclinical atherosclerosis in patients with primary Sjögren's syndrome (pSS) and its possible association with clinical and analytical parameters of the disease.
In this cross-sectional study, 38 consecutive patients with pSS were compared with 38 age and sex healthy controls. Demographic variables and classic cardiovascular risk factors (CVRFs): Hypertension, dyslipidemia, diabetes mellitus, obesity, and smoking habit were assessed in both groups, and also disease-related features were collected in pSS group. The presence of subclinical atherosclerosis was assessed by carotid ultrasound, with carotid intima-media thickness (CIMT) measurement and determination of the presence of atheromatous plaques.
Subclinical atherosclerosis presence was remarkably greater in patients with pSS than in healthy controls (OR = 4.17, 95%CI [1.27-16.54]), as well as CIMT values (0.79 ± 0.43mm vs. 0.66 ± 0.27mm; P = .02). No differences for classic CVRFs were found between both groups. An association of subclinical atherosclerosis with erythrocyte sedimentation rate (ESR) and rheumatoid factor (RF) was observed in patients with pSS.
This cohort showed a greater prevalence of subclinical atherosclerosis in patients with pSS, indicating this disease as an independent risk factor for presence of early vascular damage.
评估原发性干燥综合征（pSS）患者亚临床动脉粥样硬化的患病率及其与该疾病临床和分析参数的可能关联。
在这项横断面研究中，将38例连续的pSS患者与38例年龄和性别匹配的健康对照者进行比较。评估两组的人口统计学变量和经典心血管危险因素（CVRFs）：高血压、血脂异常、糖尿病、肥胖和吸烟习惯，同时收集pSS组的疾病相关特征。通过颈动脉超声评估亚临床动脉粥样硬化的存在情况，测量颈动脉内膜中层厚度（CIMT）并确定动脉粥样斑块的存在。
pSS患者亚临床动脉粥样硬化的发生率显著高于健康对照者（OR = 4.17，95%CI [1.27 - 16.54]），CIMT值也更高（0.79 ± 0.43mm对0.66 ± 0.27mm；P = .02）。两组之间经典CVRFs无差异。在pSS患者中观察到亚临床动脉粥样硬化与红细胞沉降率（ESR）和类风湿因子（RF）相关。
该队列显示pSS患者亚临床动脉粥样硬化的患病率更高，表明该疾病是早期血管损伤存在的独立危险因素。
