Napiórkowska-Baran Katarzyna, Schmidt Oskar, Szymczak Bartłomiej, Lubański Jakub, Doligalska Agata, Bartuzi Zbigniew
Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University Toruń, 85-067 Bydgoszcz, Poland.
Student Research Club of Clinical Immunology, Department of Allergology, Clinical Immunology and Internal Diseases, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University Toruń, 85-067 Bydgoszcz, Poland.
Curr Issues Mol Biol. 2023 Nov 1;45(11):8780-8815. doi: 10.3390/cimb45110552.
A strong relationship exists between immune dysfunction and cardiovascular disease. Immune dysregulation can promote the development of cardiovascular diseases as well as exacerbate their course. The disorders may occur due to the presence of primary immune defects (currently known as inborn errors of immunity) and the more common secondary immune deficiencies. Secondary immune deficiencies can be caused by certain chronic conditions (such as diabetes, chronic kidney disease, obesity, autoimmune diseases, or cancer), nutritional deficiencies (including both lack of nutrients and bioactive non-nutrient compounds), and medical treatments and addictive substances. This article unravels the molecular linkage between the aforementioned immune system disorders and atherosclerosis.
免疫功能障碍与心血管疾病之间存在着密切的关系。免疫失调不仅会促进心血管疾病的发展，还会加剧其病程。这些病症可能是由于原发性免疫缺陷（目前称为遗传性免疫缺陷）以及更为常见的继发性免疫缺陷所致。继发性免疫缺陷可由某些慢性疾病（如糖尿病、慢性肾病、肥胖症、自身免疫性疾病或癌症）、营养缺乏（包括营养素和生物活性非营养化合物的缺乏）以及医学治疗和成瘾物质引起。本文将揭示上述免疫系统紊乱与动脉粥样硬化之间的分子联系。
