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一例年轻成人在 IgG 治疗下发生间质性肾炎的罕见病例。

Rare case of interstitial nephritis in a young adult under IgG therapy.

机构信息

Nephrology, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal

Clínica Universitária de Nefrologia, Faculdade de Medicina da Universidade de Coimbra, Coimbra, Portugal.

出版信息

BMJ Case Rep. 2022 Feb 2;15(2):e246651. doi: 10.1136/bcr-2021-246651.

Abstract

Immunoglobulin replacement therapy is an important therapeutic approach used in different diseases, such as immunodeficiency diseases. We report a case of a 19-year-old female patient with suspected common variable immunodeficiency who started replacement therapy with IgG. During the follow-up, she developed interstitial nephritis and the subsequent workup excluded other diseases or triggers except IgG therapy.

摘要

免疫球蛋白替代疗法是一种在不同疾病中使用的重要治疗方法,如免疫缺陷疾病。我们报告了一例 19 岁女性疑似普通变异性免疫缺陷患者,她开始接受 IgG 替代治疗。在随访期间,她发生了间质性肾炎,随后的检查排除了 IgG 治疗以外的其他疾病或诱因。

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本文引用的文献

4
Adverse Effects of Immunoglobulin Therapy.免疫球蛋白治疗的不良反应。
Front Immunol. 2018 Jun 8;9:1299. doi: 10.3389/fimmu.2018.01299. eCollection 2018.
5
Drug-Induced Acute Interstitial Nephritis.药物性急性间质性肾炎
Clin J Am Soc Nephrol. 2017 Dec 7;12(12):2046-2049. doi: 10.2215/CJN.07630717. Epub 2017 Sep 11.
6
Medication-Induced Interstitial Nephritis in the 21st Century.21世纪的药物性间质性肾炎
Adv Chronic Kidney Dis. 2017 Mar;24(2):72-79. doi: 10.1053/j.ackd.2016.11.016.
7
Adverse effects of drugs on the kidney.药物对肾脏的不良反应。
Eur J Intern Med. 2016 Mar;28:1-8. doi: 10.1016/j.ejim.2015.12.001. Epub 2015 Dec 23.
8
International Consensus Document (ICON): Common Variable Immunodeficiency Disorders.国际共识文件(ICON):常见变异型免疫缺陷病
J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):38-59. doi: 10.1016/j.jaip.2015.07.025. Epub 2015 Nov 7.

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