肥胖相关基因变异(rs8050136)与 2 型糖尿病之间的脂肪量与肥胖无关。
Lack of association between fat mass and obesity-associated genetic variant (rs8050136) and type 2 diabetes mellitus.
机构信息
From the Department of Medical Laboratories Technology (Yousuf, Kannu, Almutawif, Najim), College of Applied Medical Sciences, Taibah University; from the General Directorate of Laboratories and Blood Banks (Alsehli), Ministry of Health; from the Department of Medicine (Youssouf, Alsuhaimi, Mahmood), from Pathology and Laboratory Medicine Department (Aljohani), Prince Mohammed Bin Abdulaziz Hospital, Al Madinah Al Munawarah, Kingdom of Saudi Arabia; and from the Department of Medical Laboratory Sciences (Khabour), Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.
出版信息
Saudi Med J. 2022 Feb;43(2):132-138. doi: 10.15537/smj.2022.43.2.20210822.
OBJECTIVES
To study the genotype and allele frequency of the fat mass and obesity-associated (FTO) rs8050136 A>C genetic variant and investigate its association with type 2 diabetes mekkitus (T2DM) parameters.
METHODS
This study was carried out on 118 diabetic patients and 106 healthy individuals (control) from Prince Mohammed bin Abdulaziz Hospital, Al Madinah Al Munawarah, Saudi Arabia. The TaqMan single-nucleotide polymorphism (SNP)genotyping assay was used for rs8050136 genotyping.
RESULTS
The frequency of the genotype AA was the same among T2DM and healthy control groups (21%). However, the frequency of genotype CC was 19.5% in T2DM patients and 24.5% in control individuals. There was no significant association between FTO SNP rs8050136 and an increased risk of T2DM. Furthermore, there was no association between the risk AA genotype and fasting blood glucose (=0.092), glycated hemoglobin (=0.177), or body mass index (=0.561).
CONCLUSION
Our findings show that the FTO rs8050136 A>C variant is not associated with T2DM in the Saudi population.
目的
研究肥胖相关基因（FTO）rs8050136 A>C 基因型和等位基因频率，探讨其与 2 型糖尿病（T2DM）参数的关系。
方法
本研究在沙特阿拉伯麦地那的穆罕默德·本·阿卜杜勒阿齐兹王子医院对 118 例糖尿病患者和 106 例健康个体（对照组）进行。采用 TaqMan 单核苷酸多态性（SNP）基因分型检测 rs8050136 基因型。
结果
T2DM 组和对照组 AA 基因型的频率相同（21%）。然而，T2DM 患者的 CC 基因型频率为 19.5%，对照组个体为 24.5%。FTO SNP rs8050136 与 T2DM 风险增加之间没有显著关联。此外，AA 基因型与空腹血糖（=0.092）、糖化血红蛋白（=0.177）或体重指数（=0.561）之间也没有关联。
结论
我们的研究结果表明，FTO rs8050136 A>C 变异与沙特人群的 T2DM 无关。
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